MTH1 Substrate Recognition—An Example of Specific Promiscuity

J. Willem M. Nissink; Michal Bista; Jason Breed; Nikki Carter; Kevin Embrey; Jonathan Read; Jon J. Winter-Holt

doi:10.1371/journal.pone.0151154

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Open Access

Peer-reviewed

Research Article

MTH1 Substrate Recognition—An Example of Specific Promiscuity

J. Willem M. Nissink ,

* E-mail: willem.nissink@astrazeneca.com

Affiliation Chemistry, Oncology, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Unit 310 (Darwin Building), Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, United Kingdom, and Alderley Park, Cheshire, SK10 4TG, United Kingdom
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Michal Bista,

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Unit 310 (Darwin Building), Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, United Kingdom
⨯
Jason Breed,

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Unit 310 (Darwin Building), Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, United Kingdom
⨯
Nikki Carter,

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Unit 310 (Darwin Building), Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, United Kingdom
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Kevin Embrey,

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Alderley Park, Macclesfield, SK10 4TG, United Kingdom
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Jonathan Read,

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Unit 310 (Darwin Building), Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, United Kingdom
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Jon J. Winter-Holt

Affiliation Chemistry, Oncology, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Unit 310 (Darwin Building), Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, United Kingdom, and Alderley Park, Cheshire, SK10 4TG, United Kingdom
⨯

MTH1 Substrate Recognition—An Example of Specific Promiscuity

J. Willem M. Nissink,
Michal Bista,
Jason Breed,
Nikki Carter,
Kevin Embrey,
Jonathan Read,
Jon J. Winter-Holt

Published: March 21, 2016
https://doi.org/10.1371/journal.pone.0151154

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