Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments

• Xiaohang Li,

  Affiliations State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Graduate School, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

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• Jin Cui,

  Affiliations State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Graduate School, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

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• Yang Yu,

  Affiliation Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China

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• Wei Li,

  Affiliations State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Graduate School, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

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• Yujun Hou,

  Affiliation State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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• Xin Wang,

  Affiliations State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Graduate School, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

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• Dapeng Qin,

  Affiliation Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China

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• Cun Zhao,

  Affiliations State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Graduate School, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

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• Xinsheng Yao,

  Affiliation Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China

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• Jian Zhao ,

  * E-mail: gpei@sibs.ac.cn (GP); jzhao@sibs.ac.cn (JZ)

  Affiliations State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China

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• Gang Pei

  * E-mail: gpei@sibs.ac.cn (GP); jzhao@sibs.ac.cn (JZ)

  Affiliations State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, School of Life Science and Technology, Collaborative Innovation Center for Brain Science, Tongji University, Shanghai, China

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