Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors

Winyoo Chowanadisai; Shanta M. Messerli; Daniel H. Miller; Jamie E. Medina; Joshua W. Hamilton; Mark A. Messerli; Alexander S. Brodsky

doi:10.1371/journal.pone.0151089

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Peer-reviewed

Research Article

Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors

Winyoo Chowanadisai ,

Contributed equally to this work with: Winyoo Chowanadisai, Shanta M. Messerli

Affiliations Department of Nutritional Sciences, Oklahoma State University, Stillwater, Oklahoma, United States of America, 74078, Marine Biological Laboratory, Woods Hole, Massachusetts, United States of America, 02543
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Shanta M. Messerli ,

Contributed equally to this work with: Winyoo Chowanadisai, Shanta M. Messerli

Affiliation Marine Biological Laboratory, Woods Hole, Massachusetts, United States of America, 02543
⨯
Daniel H. Miller,

Affiliations Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 02139, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, 02142
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Jamie E. Medina,

Affiliations Marine Biological Laboratory, Woods Hole, Massachusetts, United States of America, 02543, Department of Biological Sciences, Bridgewater State University, Bridgewater, Massachusetts, United States of America, 02325
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Joshua W. Hamilton,

Affiliations Marine Biological Laboratory, Woods Hole, Massachusetts, United States of America, 02543, Swenson College of Science and Engineering, University of Minnesota, Duluth, Minnesota, United States of America, 55804
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Mark A. Messerli ,

* E-mail: mark.messerli@sdstate.edu (MAM); alex_brodsky@brown.edu (ASB)

Affiliations Marine Biological Laboratory, Woods Hole, Massachusetts, United States of America, 02543, Department of Biology and Microbiology, South Dakota State University, Brookings, South Dakota, United States of America, 57007
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Alexander S. Brodsky

* E-mail: mark.messerli@sdstate.edu (MAM); alex_brodsky@brown.edu (ASB)

Affiliations Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 02139, Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America, 02903, Center for Computational Molecular Biology, Brown University, Providence, Rhode Island, United States of America, 02912
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Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors

Winyoo Chowanadisai,
Shanta M. Messerli,
Daniel H. Miller,
Jamie E. Medina,
Joshua W. Hamilton,
Mark A. Messerli,
Alexander S. Brodsky

Published: March 17, 2016
https://doi.org/10.1371/journal.pone.0151089

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Ovarian cancer
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Gene expression
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Platinum
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Microarrays
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DNA-binding proteins
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