PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma

Alok R. Singh; Shweta Joshi; Muamera Zulcic; Michael Alcaraz; Joseph R. Garlich; Guillermo A. Morales; Yoon J. Cho; Lei Bao; Michael L. Levy; Robert Newbury; Denise Malicki; Karen Messer; John Crawford; Donald L. Durden

doi:10.1371/journal.pone.0150836

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Open Access

Peer-reviewed

Research Article

PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma

Alok R. Singh,

Affiliation Department of Pediatrics, Moores Cancer Center, UC San Diego Health System, La Jolla, CA, United States of America
⨯
Shweta Joshi,

Affiliation Department of Pediatrics, Moores Cancer Center, UC San Diego Health System, La Jolla, CA, United States of America
⨯
Muamera Zulcic,

Affiliation Department of Pediatrics, Moores Cancer Center, UC San Diego Health System, La Jolla, CA, United States of America
⨯
Michael Alcaraz,

Affiliation Department of Pediatrics, Moores Cancer Center, UC San Diego Health System, La Jolla, CA, United States of America
⨯
Joseph R. Garlich,

Affiliation SignalRx Pharmaceuticals, San Diego, CA, United States of America
⨯
Guillermo A. Morales,

Affiliation SignalRx Pharmaceuticals, San Diego, CA, United States of America
⨯
Yoon J. Cho,

Affiliation Departments of Neurology and Neurosurgery, Stanford University School of Medicine, Stanford, CA, United States of America
⨯
Lei Bao,

Affiliation Biostatistics Department, Moores Cancer Center, UC San Diego Health System, La Jolla, CA, United States of America
⨯
Michael L. Levy,

Affiliation Department of Neurosurgery, UCSD Rady Children’s Hospital, La Jolla, CA, United States of America
⨯
Robert Newbury,

Affiliation Department of Pathology, UCSD Rady Children’s Hospital, La Jolla, CA, United States of America
⨯
Denise Malicki,

Affiliation Department of Pathology, UCSD Rady Children’s Hospital, La Jolla, CA, United States of America
⨯
Karen Messer,

Affiliation Biostatistics Department, Moores Cancer Center, UC San Diego Health System, La Jolla, CA, United States of America
⨯
John Crawford,

Affiliation Department of Neurosciences Division of Child Neurology, UCSD Rady Children’s Hospital, La Jolla, CA, United States of America
⨯
Donald L. Durden

* E-mail: ddurden@ucsd.edu

Affiliations Department of Pediatrics, Moores Cancer Center, UC San Diego Health System, La Jolla, CA, United States of America, Division of Pediatric Hematology-Oncology, UCSD Rady Children’s Hospital, La Jolla, CA, United States of America
⨯

PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma

Alok R. Singh,
Shweta Joshi,
Muamera Zulcic,
Michael Alcaraz,
Joseph R. Garlich,
Guillermo A. Morales,
Yoon J. Cho,
Lei Bao,
Michael L. Levy,
Robert Newbury

Published: March 3, 2016
https://doi.org/10.1371/journal.pone.0150836

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