HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity

Michael R. Nonnemacher; Vanessa Pirrone; Rui Feng; Brian Moldover; Shendra Passic; Benjamas Aiamkitsumrit; Will Dampier; Adam Wojno; Evelyn Kilareski; Brandon Blakey; Tse-Sheun Jade Ku; Sonia Shah; Neil T. Sullivan; Jeffrey M. Jacobson; Brian Wigdahl

doi:10.1371/journal.pone.0150835

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Research Article

HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity

Michael R. Nonnemacher ,

Contributed equally to this work with: Michael R. Nonnemacher, Vanessa Pirrone

Affiliations Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
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Vanessa Pirrone ,

Contributed equally to this work with: Michael R. Nonnemacher, Vanessa Pirrone

Affiliations Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
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Rui Feng,

Affiliation Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
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Brian Moldover,

Affiliation B-Tech Consulting, Ltd., Philadelphia, Pennsylvania, United States of America
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Shendra Passic,

Affiliations Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
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Benjamas Aiamkitsumrit,

Affiliations Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
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Will Dampier,

Affiliations Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
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Adam Wojno,

Affiliations Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
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Evelyn Kilareski,

Affiliations Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
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Brandon Blakey,

Affiliations Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
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Tse-Sheun Jade Ku,

Affiliations Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
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Sonia Shah,

Affiliations Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
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Neil T. Sullivan,

Affiliations Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
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Jeffrey M. Jacobson,

Affiliations Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Clinical and Translational Medicine, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Division of Infectious Disease and HIV Medicine, Department of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
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Brian Wigdahl

* E-mail: bwigdahl@drexelmed.edu

Affiliations Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Clinical and Translational Medicine, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
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HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity

Michael R. Nonnemacher,
Vanessa Pirrone,
Rui Feng,
Brian Moldover,
Shendra Passic,
Benjamas Aiamkitsumrit,
Will Dampier,
Adam Wojno,
Evelyn Kilareski,
Brandon Blakey

Published: April 21, 2016
https://doi.org/10.1371/journal.pone.0150835

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