Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes

Thomas B. Thornley; Krishna A. Agarwal; Periklis Kyriazis; Lingzhi Ma; Vaja Chipashvili; Jonathan E. Aker; Sarantis Korniotis; Eva Csizmadia; Terry B. Strom; Maria Koulmanda

doi:10.1371/journal.pone.0150792

Loading metrics

Open Access

Peer-reviewed

Research Article

Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes

Thomas B. Thornley,

Affiliation Department of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States of America
⨯
Krishna A. Agarwal ,

Contributed equally to this work with: Krishna A. Agarwal, Periklis Kyriazis

Affiliation Department of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States of America
⨯
Periklis Kyriazis ,

Contributed equally to this work with: Krishna A. Agarwal, Periklis Kyriazis

Affiliation Department of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States of America
⨯
Lingzhi Ma,

Affiliation Department of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States of America
⨯
Vaja Chipashvili,

Affiliation Department of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States of America
⨯
Jonathan E. Aker,

Affiliation Department of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States of America
⨯
Sarantis Korniotis,

Affiliation Department of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States of America
⨯
Eva Csizmadia,

Affiliation Department of Surgery, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States of America
⨯
Terry B. Strom ,

* E-mail: tstrom@bidmc.harvard.edu (TBS); mkoulman@bidmc.harvard.edu (MK)

Affiliations Department of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States of America, Department of Surgery, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States of America
⨯
Maria Koulmanda

* E-mail: tstrom@bidmc.harvard.edu (TBS); mkoulman@bidmc.harvard.edu (MK)

Affiliations Department of Medicine, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States of America, Department of Surgery, Harvard Medical School and the Transplant Institute at Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States of America
⨯

Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes

Thomas B. Thornley,
Krishna A. Agarwal,
Periklis Kyriazis,
Lingzhi Ma,
Vaja Chipashvili,
Jonathan E. Aker,
Sarantis Korniotis,
Eva Csizmadia,
Terry B. Strom,
Maria Koulmanda

Published: March 4, 2016
https://doi.org/10.1371/journal.pone.0150792

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Genetically modified animals
Is the Subject Area "Genetically modified animals" applicable to this article?

Thanks for your feedback.
Regulatory T cells
Is the Subject Area "Regulatory T cells" applicable to this article?

Thanks for your feedback.
Diabetes mellitus
Is the Subject Area "Diabetes mellitus" applicable to this article?

Thanks for your feedback.
Insulitis
Is the Subject Area "Insulitis" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Phenotypes
Is the Subject Area "Phenotypes" applicable to this article?

Thanks for your feedback.