Dapagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, Acutely Reduces Energy Expenditure in BAT via Neural Signals in Mice

Yumiko Chiba; Tetsuya Yamada; Sohei Tsukita; Kei Takahashi; Yuichiro Munakata; Yuta Shirai; Shinjiro Kodama; Yoichiro Asai; Takashi Sugisawa; Kenji Uno; Shojiro Sawada; Junta Imai; Kazuhiro Nakamura; Hideki Katagiri

doi:10.1371/journal.pone.0150756

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Open Access

Peer-reviewed

Research Article

Dapagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, Acutely Reduces Energy Expenditure in BAT via Neural Signals in Mice

Yumiko Chiba,

Affiliation Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan
⨯
Tetsuya Yamada ,

* E-mail: yamatetsu-tky@umin.ac.jp

Affiliation Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan
⨯
Sohei Tsukita,

Affiliation Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan
⨯
Kei Takahashi,

Affiliation Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan
⨯
Yuichiro Munakata,

Affiliation Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan
⨯
Yuta Shirai,

Affiliation Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan
⨯
Shinjiro Kodama,

Affiliation Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan
⨯
Yoichiro Asai,

Affiliation Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan
⨯
Takashi Sugisawa,

Affiliation Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan
⨯
Kenji Uno,

Affiliation Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan
⨯
Shojiro Sawada,

Affiliation Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan
⨯
Junta Imai,

Affiliation Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan
⨯
Kazuhiro Nakamura,

Affiliation Department of Integrative Physiology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan
⨯
Hideki Katagiri

Affiliations Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan, Japan Agency for Medical Research and Development (AMED), CREST, Sendai, 980-8575, Japan
⨯

Dapagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, Acutely Reduces Energy Expenditure in BAT via Neural Signals in Mice

Yumiko Chiba,
Tetsuya Yamada,
Sohei Tsukita,
Kei Takahashi,
Yuichiro Munakata,
Yuta Shirai,
Shinjiro Kodama,
Yoichiro Asai,
Takashi Sugisawa,
Kenji Uno

Published: March 10, 2016
https://doi.org/10.1371/journal.pone.0150756

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