Human Monocyte-Derived Osteoclasts Are Targeted by Staphylococcal Pore-Forming Toxins and Superantigens

Sacha Flammier; Jean-Philippe Rasigade; Cédric Badiou; Thomas Henry; François Vandenesch; Frédéric Laurent; Sophie Trouillet-Assant

doi:10.1371/journal.pone.0150693

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Peer-reviewed

Research Article

Human Monocyte-Derived Osteoclasts Are Targeted by Staphylococcal Pore-Forming Toxins and Superantigens

Sacha Flammier ,

* E-mail: sacha.flammier@inserm.fr

Affiliation Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, 103 grande rue de la Croix Rousse, 69004 Lyon, France
⨯
Jean-Philippe Rasigade,

Affiliation Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, 103 grande rue de la Croix Rousse, 69004 Lyon, France
⨯
Cédric Badiou,

Affiliation Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, 103 grande rue de la Croix Rousse, 69004 Lyon, France
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Thomas Henry,

Affiliation Centre International de Recherche en Infectiologie, INSERM U1111, Inflammasome, bacterial infections and autoinflammatory diseases, University of Lyon 1, 21 avenue Tony Garnier, 69365 Lyon cedex 07, France
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François Vandenesch,

Affiliation Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, 103 grande rue de la Croix Rousse, 69004 Lyon, France
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Frédéric Laurent,

Affiliation Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, 103 grande rue de la Croix Rousse, 69004 Lyon, France
⨯
Sophie Trouillet-Assant

Affiliation Centre International de Recherche en Infectiologie, INSERM U1111, Pathogenesis of staphylococcal infections, University of Lyon 1, Department of Clinical Microbiology, Northern Hospital Group, Hospices Civils de Lyon, 103 grande rue de la Croix Rousse, 69004 Lyon, France
⨯

Human Monocyte-Derived Osteoclasts Are Targeted by Staphylococcal Pore-Forming Toxins and Superantigens

Sacha Flammier,
Jean-Philippe Rasigade,
Cédric Badiou,
Thomas Henry,
François Vandenesch,
Frédéric Laurent,
Sophie Trouillet-Assant

Published: March 2, 2016
https://doi.org/10.1371/journal.pone.0150693

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Osteoclasts
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Toxins
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Macrophages
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Staphylococcus aureus
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Bone resorption
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Staphylococcus
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Cytotoxicity
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Monocytes
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