SMN Protein Can Be Reliably Measured in Whole Blood with an Electrochemiluminescence (ECL) Immunoassay: Implications for Clinical Trials

Phillip Zaworski; Katharine M. von Herrmann; Shannon Taylor; Sara S. Sunshine; Kathleen McCarthy; Nicole Risher; Tara Newcomb; Marla Weetall; Thomas W. Prior; Kathryn J. Swoboda; Karen S. Chen; Sergey Paushkin

doi:10.1371/journal.pone.0150640

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Open Access

Peer-reviewed

Research Article

SMN Protein Can Be Reliably Measured in Whole Blood with an Electrochemiluminescence (ECL) Immunoassay: Implications for Clinical Trials

Phillip Zaworski ,

Contributed equally to this work with: Phillip Zaworski, Katharine M. von Herrmann

Affiliation PharmOptima, Portage, Michigan, United States of America
⨯
Katharine M. von Herrmann ,

Contributed equally to this work with: Phillip Zaworski, Katharine M. von Herrmann

Current address: Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Affiliation Spinal Muscular Atrophy Foundation, New York, New York, United States of America
⨯
Shannon Taylor,

Affiliation PharmOptima, Portage, Michigan, United States of America
⨯
Sara S. Sunshine,

Affiliation Spinal Muscular Atrophy Foundation, New York, New York, United States of America
⨯
Kathleen McCarthy,

Current address: F. Hoffmann-La Roche Ltd, Basel, 4070, Switzerland

Affiliation Spinal Muscular Atrophy Foundation, New York, New York, United States of America
⨯
Nicole Risher,

Affiliation PTC Therapeutics, South Plainfield, New Jersey, United States of America
⨯
Tara Newcomb,

Affiliation Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
⨯
Marla Weetall,

Affiliation PTC Therapeutics, South Plainfield, New Jersey, United States of America
⨯
Thomas W. Prior,

Affiliation Department of Molecular Pathology, Wexner Medical Center, Ohio State University, Columbus, Ohio, United States of America
⨯
Kathryn J. Swoboda,

Current address: Center for Human Genetic Research, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Affiliation Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
⨯
Karen S. Chen,

Affiliation Spinal Muscular Atrophy Foundation, New York, New York, United States of America
⨯
Sergey Paushkin

* E-mail: spaushkin@smafoundation.org

Affiliation Spinal Muscular Atrophy Foundation, New York, New York, United States of America
⨯

SMN Protein Can Be Reliably Measured in Whole Blood with an Electrochemiluminescence (ECL) Immunoassay: Implications for Clinical Trials

Phillip Zaworski,
Katharine M. von Herrmann,
Shannon Taylor,
Sara S. Sunshine,
Kathleen McCarthy,
Nicole Risher,
Tara Newcomb,
Marla Weetall,
Thomas W. Prior,
Kathryn J. Swoboda

Published: March 8, 2016
https://doi.org/10.1371/journal.pone.0150640

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