Inhibition of CXCR4 by LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic Malignancies

Sheng-Bin Peng; Xiaoyi Zhang; Donald Paul; Lisa M. Kays; Ming Ye; Peter Vaillancourt; Michele Dowless; Louis F. Stancato; Julie Stewart; Mark T. Uhlik; Haiyan Long; Shaoyou Chu; Victor H. Obungu

doi:10.1371/journal.pone.0150585

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Open Access

Peer-reviewed

Research Article

Inhibition of CXCR4 by LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic Malignancies

Sheng-Bin Peng ,

* E-mail: Peng_sheng-bin@lilly.com

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, 46285, United States of America
⨯
Xiaoyi Zhang,

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, 46285, United States of America
⨯
Donald Paul,

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, 46285, United States of America
⨯
Lisa M. Kays,

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, 46285, United States of America
⨯
Ming Ye,

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, 46285, United States of America
⨯
Peter Vaillancourt,

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, 46285, United States of America
⨯
Michele Dowless,

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, 46285, United States of America
⨯
Louis F. Stancato,

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, 46285, United States of America
⨯
Julie Stewart,

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, 46285, United States of America
⨯
Mark T. Uhlik,

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, 46285, United States of America
⨯
Haiyan Long,

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, 46285, United States of America
⨯
Shaoyou Chu,

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, 46285, United States of America
⨯
Victor H. Obungu

Affiliation Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, 46285, United States of America
⨯

Inhibition of CXCR4 by LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic Malignancies

Sheng-Bin Peng,
Xiaoyi Zhang,
Donald Paul,
Lisa M. Kays,
Ming Ye,
Peter Vaillancourt,
Michele Dowless,
Louis F. Stancato,
Julie Stewart,
Mark T. Uhlik

Published: March 8, 2016
https://doi.org/10.1371/journal.pone.0150585

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