Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung

Olga Rafikova; Mary L. Meadows; Jason M. Kinchen; Robert P. Mohney; Emin Maltepe; Ankit A. Desai; Jason X.-J. Yuan; Joe G. N. Garcia; Jeffrey R. Fineman; Ruslan Rafikov; Stephen M. Black

doi:10.1371/journal.pone.0150480

Loading metrics

Open Access

Peer-reviewed

Research Article

Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung

Olga Rafikova,

Affiliations Division of Translational and Regenerative Medicine, The University of Arizona, Tucson, Arizona, United States of America, Department of Medicine, The University of Arizona, Tucson, Arizona, United States of America
⨯
Mary L. Meadows,

Affiliation Vascular Biology Center, Georgia Regents University, Augusta, Georgia, United States of America
⨯
Jason M. Kinchen,

Affiliation Metabolon, Durham, North Carolina, United States of America
⨯
Robert P. Mohney,

Affiliation Metabolon, Durham, North Carolina, United States of America
⨯
Emin Maltepe,

Affiliation Division of Neonatology, University of California San Francisco, San Francisco, California, United States of America
⨯
Ankit A. Desai,

Affiliation Department of Medicine, The University of Arizona, Tucson, Arizona, United States of America
⨯
Jason X.-J. Yuan,

Affiliations Division of Translational and Regenerative Medicine, The University of Arizona, Tucson, Arizona, United States of America, Department of Medicine, The University of Arizona, Tucson, Arizona, United States of America
⨯
Joe G. N. Garcia,

Affiliation Department of Medicine, The University of Arizona, Tucson, Arizona, United States of America
⨯
Jeffrey R. Fineman,

Affiliations Department of Pediatrics, University of California San Francisco, San Francisco, California, United States of America, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America
⨯
Ruslan Rafikov ,

* E-mail: ruslanrafikov@email.arizona.edu

Affiliations Division of Translational and Regenerative Medicine, The University of Arizona, Tucson, Arizona, United States of America, Department of Medicine, The University of Arizona, Tucson, Arizona, United States of America
⨯
Stephen M. Black

Affiliations Division of Translational and Regenerative Medicine, The University of Arizona, Tucson, Arizona, United States of America, Department of Medicine, The University of Arizona, Tucson, Arizona, United States of America
⨯

Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung

Olga Rafikova,
Mary L. Meadows,
Jason M. Kinchen,
Robert P. Mohney,
Emin Maltepe,
Ankit A. Desai,
Jason X.-J. Yuan,
Joe G. N. Garcia,
Jeffrey R. Fineman,
Ruslan Rafikov

Published: March 3, 2016
https://doi.org/10.1371/journal.pone.0150480

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Fatty acids
Is the Subject Area "Fatty acids" applicable to this article?

Thanks for your feedback.
Cardiac ventricles
Is the Subject Area "Cardiac ventricles" applicable to this article?

Thanks for your feedback.
Glucose metabolism
Is the Subject Area "Glucose metabolism" applicable to this article?

Thanks for your feedback.
Metabolites
Is the Subject Area "Metabolites" applicable to this article?

Thanks for your feedback.
Arginine
Is the Subject Area "Arginine" applicable to this article?

Thanks for your feedback.
Nitric oxide
Is the Subject Area "Nitric oxide" applicable to this article?

Thanks for your feedback.
Metabolic pathways
Is the Subject Area "Metabolic pathways" applicable to this article?

Thanks for your feedback.