Generation and Characterization of a Human/Mouse Chimeric GD2-Mimicking Anti-Idiotype Antibody Ganglidiximab for Active Immunotherapy against Neuroblastoma

Open Access

Peer-reviewed

Research Article

Generation and Characterization of a Human/Mouse Chimeric GD₂-Mimicking Anti-Idiotype Antibody Ganglidiximab for Active Immunotherapy against Neuroblastoma

Christin Eger ,

¶‡ These two authors are co-first authors of this work.

Affiliation Department of Pediatric Oncology and Hematology, University Medicine Greifswald, 17475, Greifswald, Germany
⨯
Nikolai Siebert ,

* E-mail: nikolai.siebert@uni-greifswald.de

¶‡ These two authors are co-first authors of this work.

Affiliation Department of Pediatric Oncology and Hematology, University Medicine Greifswald, 17475, Greifswald, Germany
⨯
Diana Seidel,

Affiliation Department of Pediatric Oncology and Hematology, University Medicine Greifswald, 17475, Greifswald, Germany
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Maxi Zumpe,

Affiliation Department of Pediatric Oncology and Hematology, University Medicine Greifswald, 17475, Greifswald, Germany
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Madlen Jüttner,

Affiliation Department of Pediatric Oncology and Hematology, University Medicine Greifswald, 17475, Greifswald, Germany
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Sven Brandt,

Affiliation ZIK HIKE, Center for Innovation Competence: Humoral Immune Reactions in Cardiovascular Diseases, University of Greifswald, Greifswald, Germany
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Hans-Peter Müller,

Affiliation ZIK HIKE, Center for Innovation Competence: Humoral Immune Reactions in Cardiovascular Diseases, University of Greifswald, Greifswald, Germany
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Holger N. Lode

Affiliation Department of Pediatric Oncology and Hematology, University Medicine Greifswald, 17475, Greifswald, Germany
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CHO cells
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Enzyme-linked immunoassays
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Binding analysis
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Plasmid construction
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Cloning
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Centrifugation
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Agarose gel electrophoresis
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Vaccination and immunization
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