Genomic Instability Associated with p53 Knockdown in the Generation of Huntington’s Disease Human Induced Pluripotent Stem Cells

Andrew M. Tidball; M. Diana Neely; Reed Chamberlin; Asad A. Aboud; Kevin K. Kumar; Bingying Han; Miles R. Bryan; Michael Aschner; Kevin C. Ess; Aaron B. Bowman

doi:10.1371/journal.pone.0150372

Loading metrics

Open Access

Peer-reviewed

Research Article

Genomic Instability Associated with p53 Knockdown in the Generation of Huntington’s Disease Human Induced Pluripotent Stem Cells

Andrew M. Tidball,

Affiliations Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, 37240, United States of America, Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, United States of America
⨯
M. Diana Neely,

Affiliations Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, 37240, United States of America, Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, United States of America
⨯
Reed Chamberlin,

Affiliation Genetics Associates Inc., Nashville, TN, 37203, United States of America
⨯
Asad A. Aboud,

Affiliation Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, 37240, United States of America
⨯
Kevin K. Kumar,

Affiliations Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, 37240, United States of America, Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, United States of America
⨯
Bingying Han,

Affiliation Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, 37240, United States of America
⨯
Miles R. Bryan,

Affiliations Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, 37240, United States of America, Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, United States of America
⨯
Michael Aschner,

Affiliation Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, United States of America
⨯
Kevin C. Ess,

Affiliations Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, United States of America, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37240, United States of America
⨯
Aaron B. Bowman

* E-mail: aaron.bowman@vanderbilt.edu

Affiliations Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, 37240, United States of America, Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, United States of America, Center in Molecular Toxicology, Vanderbilt University, Nashville, TN, 37232, United States of America
⨯

Genomic Instability Associated with p53 Knockdown in the Generation of Huntington’s Disease Human Induced Pluripotent Stem Cells

Andrew M. Tidball,
M. Diana Neely,
Reed Chamberlin,
Asad A. Aboud,
Kevin K. Kumar,
Bingying Han,
Miles R. Bryan,
Michael Aschner,
Kevin C. Ess,
Aaron B. Bowman

Published: March 16, 2016
https://doi.org/10.1371/journal.pone.0150372

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

DNA damage
Is the Subject Area "DNA damage" applicable to this article?

Thanks for your feedback.
Huntington disease
Is the Subject Area "Huntington disease" applicable to this article?

Thanks for your feedback.
Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.
Genomics
Is the Subject Area "Genomics" applicable to this article?

Thanks for your feedback.
Induced pluripotent stem cells
Is the Subject Area "Induced pluripotent stem cells" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Karyotypes
Is the Subject Area "Karyotypes" applicable to this article?

Thanks for your feedback.
Cell cycle and cell division
Is the Subject Area "Cell cycle and cell division" applicable to this article?

Thanks for your feedback.