Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress

Luiza A. Rabelo; Mihail Todiras; Valéria Nunes-Souza; Fatimunnisa Qadri; István András Szijártó; Maik Gollasch; Josef M. Penninger; Michael Bader; Robson A. Santos; Natalia Alenina

doi:10.1371/journal.pone.0150255

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Open Access

Peer-reviewed

Research Article

Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress

Luiza A. Rabelo,

Affiliations Max-Delbrück-Center for Molecular Medicine, Berlin, Germany, Laboratório de Reatividade Cardiovascular, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil, Instituto Nacional de Ciência e Tecnologia em NanoBiofarmacêutica (NanoBIOFAR)
⨯
Mihail Todiras,

Affiliations Max-Delbrück-Center for Molecular Medicine, Berlin, Germany, Instituto Nacional de Ciência e Tecnologia em NanoBiofarmacêutica (NanoBIOFAR)
⨯
Valéria Nunes-Souza,

Affiliations Max-Delbrück-Center for Molecular Medicine, Berlin, Germany, Laboratório de Reatividade Cardiovascular, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil, Instituto Nacional de Ciência e Tecnologia em NanoBiofarmacêutica (NanoBIOFAR)
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Fatimunnisa Qadri,

Affiliations Max-Delbrück-Center for Molecular Medicine, Berlin, Germany, Charité University Medicine, Berlin, Germany
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István András Szijártó,

Affiliation Nephrology/Intensive Care, Charité Campus Virchow Klinikum, Experimental and Clinical Research Center (ECRC), Berlin, Germany
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Maik Gollasch,

Affiliation Nephrology/Intensive Care, Charité Campus Virchow Klinikum, Experimental and Clinical Research Center (ECRC), Berlin, Germany
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Josef M. Penninger,

Affiliation Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria
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Michael Bader,

Affiliations Max-Delbrück-Center for Molecular Medicine, Berlin, Germany, Instituto Nacional de Ciência e Tecnologia em NanoBiofarmacêutica (NanoBIOFAR), Charité University Medicine, Berlin, Germany, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
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Robson A. Santos,

Affiliations Instituto Nacional de Ciência e Tecnologia em NanoBiofarmacêutica (NanoBIOFAR), Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
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Natalia Alenina

* E-mail: alenina@mdc-berlin.de

Affiliations Max-Delbrück-Center for Molecular Medicine, Berlin, Germany, Instituto Nacional de Ciência e Tecnologia em NanoBiofarmacêutica (NanoBIOFAR), Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
⨯

Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress

Luiza A. Rabelo,
Mihail Todiras,
Valéria Nunes-Souza,
Fatimunnisa Qadri,
István András Szijártó,
Maik Gollasch,
Josef M. Penninger,
Michael Bader,
Robson A. Santos,
Natalia Alenina

Published: April 12, 2016
https://doi.org/10.1371/journal.pone.0150255

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