Inhibition of TREM-1 and Dectin-1 Alleviates the Severity of Fungal Keratitis by Modulating Innate Immune Responses

Jing Zhong; Weilan Huang; Qiuchan Deng; Minhao Wu; Huaili Jiang; Xiaolei Lin; Yifang Sun; Xi Huang; Jin Yuan

doi:10.1371/journal.pone.0150114

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Open Access

Peer-reviewed

Research Article

Inhibition of TREM-1 and Dectin-1 Alleviates the Severity of Fungal Keratitis by Modulating Innate Immune Responses

Jing Zhong ,

Contributed equally to this work with: Jing Zhong, Weilan Huang

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Zhongshan School of Medicine, SunYat-sen University, Guangzhou, 510064, China
⨯
Weilan Huang ,

Contributed equally to this work with: Jing Zhong, Weilan Huang

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Zhongshan School of Medicine, SunYat-sen University, Guangzhou, 510064, China
⨯
Qiuchan Deng,

Affiliations Department of Immunology, Institute of Human virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, 510080, China
⨯
Minhao Wu,

Affiliations Department of Immunology, Institute of Human virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, 510080, China
⨯
Huaili Jiang,

Affiliation Department of Otolaryngology Head and Neck Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Xiaolei Lin,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Zhongshan School of Medicine, SunYat-sen University, Guangzhou, 510064, China
⨯
Yifang Sun,

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Zhongshan School of Medicine, SunYat-sen University, Guangzhou, 510064, China
⨯
Xi Huang ,

* E-mail: huangxi6@mail.sysu.edu.cn (XH); yuanjincornea@126.com (JY)

Affiliations State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Zhongshan School of Medicine, SunYat-sen University, Guangzhou, 510064, China, Department of Immunology, Institute of Human virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China, Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, 510080, China
⨯
Jin Yuan

* E-mail: huangxi6@mail.sysu.edu.cn (XH); yuanjincornea@126.com (JY)

Affiliation State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Zhongshan School of Medicine, SunYat-sen University, Guangzhou, 510064, China
⨯

Inhibition of TREM-1 and Dectin-1 Alleviates the Severity of Fungal Keratitis by Modulating Innate Immune Responses

Jing Zhong,
Weilan Huang,
Qiuchan Deng,
Minhao Wu,
Huaili Jiang,
Xiaolei Lin,
Yifang Sun,
Xi Huang,
Jin Yuan

Published: March 10, 2016
https://doi.org/10.1371/journal.pone.0150114

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