Constitutively Elevated Blood Serotonin Is Associated with Bone Loss and Type 2 Diabetes in Rats

Igor Erjavec; Tatjana Bordukalo-Niksic; Jelena Brkljacic; Danka Grcevic; Gordana Mokrovic; Maja Kesic; Dunja Rogic; William Zavadoski; Vishwas M. Paralkar; Lovorka Grgurevic; Vladimir Trkulja; Lipa Cicin-Sain; Slobodan Vukicevic

doi:10.1371/journal.pone.0150102

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Peer-reviewed

Research Article

Constitutively Elevated Blood Serotonin Is Associated with Bone Loss and Type 2 Diabetes in Rats

Igor Erjavec ,

Contributed equally to this work with: Igor Erjavec, Tatjana Bordukalo-Niksic

Affiliation Laboratory of Mineralized Tissues, Center for Translational and Clinical Research, School of Medicine, University of Zagreb, Zagreb, Croatia
⨯
Tatjana Bordukalo-Niksic ,

Contributed equally to this work with: Igor Erjavec, Tatjana Bordukalo-Niksic

Affiliation Laboratory of Mineralized Tissues, Center for Translational and Clinical Research, School of Medicine, University of Zagreb, Zagreb, Croatia
⨯
Jelena Brkljacic,

Affiliation Laboratory of Mineralized Tissues, Center for Translational and Clinical Research, School of Medicine, University of Zagreb, Zagreb, Croatia
⨯
Danka Grcevic,

Affiliation Department of Physiology and Immunology, School of Medicine, University of Zagreb, Zagreb, Croatia
⨯
Gordana Mokrovic,

Affiliation Laboratory for Neurochemistry and Molecular Neurobiology, Molecular Biology Department, Rudjer Boskovic Institute, Zagreb, Croatia
⨯
Maja Kesic,

Affiliation Laboratory for Neurochemistry and Molecular Neurobiology, Molecular Biology Department, Rudjer Boskovic Institute, Zagreb, Croatia
⨯
Dunja Rogic,

Affiliation Clinical Hospital Center Zagreb, Zagreb, Croatia
⨯
William Zavadoski,

Affiliation Karos Pharmaceuticals, New Haven, CT, United States of America
⨯
Vishwas M. Paralkar,

Affiliation Karos Pharmaceuticals, New Haven, CT, United States of America
⨯
Lovorka Grgurevic,

Affiliation Laboratory of Mineralized Tissues, Center for Translational and Clinical Research, School of Medicine, University of Zagreb, Zagreb, Croatia
⨯
Vladimir Trkulja,

Affiliation Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia
⨯
Lipa Cicin-Sain,

Affiliation Laboratory for Neurochemistry and Molecular Neurobiology, Molecular Biology Department, Rudjer Boskovic Institute, Zagreb, Croatia
⨯
Slobodan Vukicevic

* E-mail: vukicev@mef.hr

Affiliation Laboratory of Mineralized Tissues, Center for Translational and Clinical Research, School of Medicine, University of Zagreb, Zagreb, Croatia
⨯

Constitutively Elevated Blood Serotonin Is Associated with Bone Loss and Type 2 Diabetes in Rats

Igor Erjavec,
Tatjana Bordukalo-Niksic,
Jelena Brkljacic,
Danka Grcevic,
Gordana Mokrovic,
Maja Kesic,
Dunja Rogic,
William Zavadoski,
Vishwas M. Paralkar,
Lovorka Grgurevic

Published: February 23, 2016
https://doi.org/10.1371/journal.pone.0150102

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Insulin
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Osteoclasts
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Osteoblasts
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Serotonin
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Blood plasma
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Bone remodeling
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