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Open Access
Peer-reviewed
Research Article
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds
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Gregory J. Crowther ,
* E-mail: crowther@uw.edu (GJC); ojo67kk@uw.edu (KKO)
Affiliation Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Heidi K. Hillesland,
Affiliation Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Katelyn R. Keyloun,
Affiliation Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Molly C. Reid,
Affiliation Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Maria Jose Lafuente-Monasterio,
Affiliation Tres Cantos Medicines Development Campus, GlaxoSmithKline, Tres Cantos, Madrid, Spain
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Sonja Ghidelli-Disse,
Affiliation Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline R&D, Heidelberg, Germany
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Stephen E. Leonard,
Affiliation Department of Chemistry, University of Washington, Seattle, Washington, United States of America
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Panqing He,
Affiliation Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Jackson C. Jones,
Affiliation Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Mallory M. Krahn,
Affiliation Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Jack S. Mo,
Affiliation Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Kartheek S. Dasari,
Affiliation Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Anna M. W. Fox,
Affiliation Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Markus Boesche,
Affiliation Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline R&D, Heidelberg, Germany
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Majida El Bakkouri,
Affiliation Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
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Kasey L. Rivas,
Affiliation Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Didier Leroy,
Affiliation Drug Discovery, Medicines for Malaria Venture, Geneva, Switzerland
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Raymond Hui,
Affiliation Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
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Gerard Drewes,
Affiliation Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline R&D, Heidelberg, Germany
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Dustin J. Maly,
Affiliation Department of Chemistry, University of Washington, Seattle, Washington, United States of America
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Wesley C. Van Voorhis,
Affiliation Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Kayode K. Ojo
* E-mail: crowther@uw.edu (GJC); ojo67kk@uw.edu (KKO)
Affiliation Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, United States of America
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Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds
- Gregory J. Crowther,
- Heidi K. Hillesland,
- Katelyn R. Keyloun,
- Molly C. Reid,
- Maria Jose Lafuente-Monasterio,
- Sonja Ghidelli-Disse,
- Stephen E. Leonard,
- Panqing He,
- Jackson C. Jones,
- Mallory M. Krahn
- Published: March 2, 2016
- https://doi.org/10.1371/journal.pone.0149996