Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia Cells

• Alessandra Chiarenza,

  Affiliation Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy

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• Fabrizio Manetti,

  Affiliation Department of Biotechnology Chemistry and Pharmacy, University of Siena, Siena, Italy

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• Elena Petricci,

  Affiliation Department of Biotechnology Chemistry and Pharmacy, University of Siena, Siena, Italy

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• Martial Ruat,

  Affiliation CNRS, UMR-9197, Neuroscience Paris- Saclay Institute, Molecules Circuits Department, Signal Transduction and Developmental Neuropharmacology Team, Gif-sur-Yvette, France

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• Antonella Naldini,

  Affiliation Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy

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• Maurizio Taddei,

  Affiliation Department of Biotechnology Chemistry and Pharmacy, University of Siena, Siena, Italy

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• Fabio Carraro

  * E-mail: Fabio.Carraro@unisi.it

  Affiliations Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy, Istituto Toscano Tumori, Siena, Italy

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