EspP, an Extracellular Serine Protease from Enterohemorrhagic E. coli, Reduces Coagulation Factor Activities, Reduces Clot Strength, and Promotes Clot Lysis

• Kevin H. M. Kuo ,

  Contributed equally to this work with: Kevin H. M. Kuo, Shekeb Khan

  * E-mail: kevin.kuo@uhn.ca

  Affiliation Division of Medical Oncology and Hematology, University Health Network, Toronto, ON, Canada

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• Shekeb Khan ,

  Contributed equally to this work with: Kevin H. M. Kuo, Shekeb Khan

  Affiliations Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada

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• Margaret L. Rand,

  Affiliations Division of Hematology, Hospital for Sick Children, Toronto, ON, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, Department of Biochemistry, University of Toronto, Toronto, ON, Canada

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• Hira S. Mian,

  Affiliation Department of Medicine, University of Toronto, Toronto, ON, Canada

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• Elena Brnjac,

  Affiliation Department of Clinical Pathology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

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• Linda E. Sandercock,

  Affiliation Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada

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• Indira Akula,

  Affiliation Program in Molecular Structure and Function, The Hospital for Sick Children Research Institute, Toronto, ON, Canada

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• Jean-Philippe Julien,

  Affiliations Program in Molecular Structure and Function, The Hospital for Sick Children Research Institute, Toronto, ON, Canada, Department of Biochemistry, University of Toronto, Toronto, ON, Canada, Department of Immunology, University of Toronto, Toronto, ON, Canada

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• Emil F. Pai,

  Affiliations Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada, Department of Biochemistry, University of Toronto, Toronto, ON, Canada, Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

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• Alden E. Chesney

  Affiliation Department of Clinical Pathology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

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