Tolerability and Pharmacokinetic Evaluation of Inhaled Dry Powder Tobramycin Free Base in Non-Cystic Fibrosis Bronchiectasis Patients

• Marcel Hoppentocht ,

  Contributed equally to this work with: Marcel Hoppentocht, Onno W. Akkerman

  * E-mail: m.hoppentocht@rug.nl

  Affiliation Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, the Netherlands

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• Onno W. Akkerman ,

  Contributed equally to this work with: Marcel Hoppentocht, Onno W. Akkerman

  Affiliation Department of Pulmonary Diseases and Tuberculosis, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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• Paul Hagedoorn,

  Affiliation Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, the Netherlands

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• Jan-Willem C. Alffenaar,

  Affiliation Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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• Tjip S. van der Werf,

  Affiliations Department of Pulmonary Diseases and Tuberculosis, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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• Huib A. M. Kerstjens,

  Affiliation Department of Pulmonary Diseases and Tuberculosis, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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• Henderik W. Frijlink,

  Affiliation Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, the Netherlands

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• Anne H. de Boer

  Affiliation Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, the Netherlands

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