Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity

Yang Shu; Jie Ming; Pei Zhang; Qingzhi Wang; Fengjuan Jiao; Bo Tian

doi:10.1371/journal.pone.0149739

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Peer-reviewed

Research Article

Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity

Yang Shu,

Affiliations Department of Neurobiology, Tongji Medical School, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei Province, 430030, P. R. China, Central laboratory, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, Jiangsu Province, 212000, P. R. China
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Jie Ming,

Affiliation Wuhan Union hospital, Tongji Medical School, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province, 430022, P. R. China
⨯
Pei Zhang,

Affiliations Department of Neurobiology, Tongji Medical School, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei Province, 430030, P. R. China, Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei Province, 430030, P. R. China, Key Laboratory of Neurological Diseases, Ministry of Education, 13 Hangkong Road, Wuhan, Hubei Province, 430030, P. R. China
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Qingzhi Wang,

Affiliation Department of Neurobiology, Tongji Medical School, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei Province, 430030, P. R. China
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Fengjuan Jiao,

Affiliation Department of Neurobiology, Tongji Medical School, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei Province, 430030, P. R. China
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Bo Tian

* E-mail: tianbo@mails.tjmu.edu.cn

Affiliations Department of Neurobiology, Tongji Medical School, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei Province, 430030, P. R. China, Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei Province, 430030, P. R. China, Key Laboratory of Neurological Diseases, Ministry of Education, 13 Hangkong Road, Wuhan, Hubei Province, 430030, P. R. China
⨯

Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity

Yang Shu,
Jie Ming,
Pei Zhang,
Qingzhi Wang,
Fengjuan Jiao,
Bo Tian

Published: March 1, 2016
https://doi.org/10.1371/journal.pone.0149739

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Phosphorylation
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Immunoprecipitation
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Neurons
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Neuronal death
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In vitro kinase assay
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Transfection
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Parkinson disease
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