Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor

• Ekaterina N. Lyukmanova ,

  Contributed equally to this work with: Ekaterina N. Lyukmanova, Mikhail A. Shulepko

  * E-mail: ekaterina-lyukmanova@yandex.ru

  Affiliations Biological Department, Lomonosov Moscow State University, Moscow, Russian Federation, Department of Bioengineering, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

  ⨯
• Mikhail A. Shulepko ,

  Contributed equally to this work with: Ekaterina N. Lyukmanova, Mikhail A. Shulepko

  Affiliations Biological Department, Lomonosov Moscow State University, Moscow, Russian Federation, Department of Bioengineering, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

  ⨯
• Denis Kudryavtsev,

  Affiliation Department of Molecular Basics of Neurosignalling, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

  ⨯
• Maxim L. Bychkov,

  Affiliations Biological Department, Lomonosov Moscow State University, Moscow, Russian Federation, Department of Bioengineering, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

  ⨯
• Dmitrii S. Kulbatskii,

  Affiliations Biological Department, Lomonosov Moscow State University, Moscow, Russian Federation, Department of Bioengineering, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

  ⨯
• Igor E. Kasheverov,

  Affiliation Department of Molecular Basics of Neurosignalling, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

  ⨯
• Maria V. Astapova,

  Affiliation Department of Structural Biology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

  ⨯
• Alexey V. Feofanov,

  Affiliations Biological Department, Lomonosov Moscow State University, Moscow, Russian Federation, Department of Structural Biology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

  ⨯
• Morten S. Thomsen,

  Affiliations Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark, Neurobiology Research Unit, University Hospital, Copenhagen, Copenhagen, Denmark

  ⨯
• Jens D. Mikkelsen,

  Affiliation Neurobiology Research Unit, University Hospital, Copenhagen, Copenhagen, Denmark

  ⨯
• Zakhar O. Shenkarev,

  Affiliations Biological Department, Lomonosov Moscow State University, Moscow, Russian Federation, Department of Structural Biology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation, Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow Region, Russian Federation

  ⨯
• Victor I. Tsetlin,

  Affiliation Department of Molecular Basics of Neurosignalling, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

  ⨯
• Dmitry A. Dolgikh,

  Affiliations Biological Department, Lomonosov Moscow State University, Moscow, Russian Federation, Department of Bioengineering, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

  ⨯
• Mikhail P. Kirpichnikov

  Affiliations Biological Department, Lomonosov Moscow State University, Moscow, Russian Federation, Department of Bioengineering, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

  ⨯