A Novel Synthetic TLR-4 Agonist Adjuvant Increases the Protective Response to a Clinical-Stage West Nile Virus Vaccine Antigen in Multiple Formulations

Neal Van Hoeven; Sharvari Waghmare Joshi; Ghislain Ismael Nana; Angela Bosco-Lauth; Christopher Fox; Richard A. Bowen; David E. Clements; Timothy Martyak; D. Elliot Parks; Susan Baldwin; Steven G. Reed; Rhea N. Coler

doi:10.1371/journal.pone.0149610

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Open Access

Peer-reviewed

Research Article

A Novel Synthetic TLR-4 Agonist Adjuvant Increases the Protective Response to a Clinical-Stage West Nile Virus Vaccine Antigen in Multiple Formulations

Neal Van Hoeven ,

* E-mail: neal.vanhoeven@idri.org

Affiliation Infectious Disease Research Institute, 1616 Eastlake Ave E., Seattle, WA 98103, United States of America
⨯
Sharvari Waghmare Joshi,

Affiliation Infectious Disease Research Institute, 1616 Eastlake Ave E., Seattle, WA 98103, United States of America
⨯
Ghislain Ismael Nana,

Affiliation Infectious Disease Research Institute, 1616 Eastlake Ave E., Seattle, WA 98103, United States of America
⨯
Angela Bosco-Lauth,

Affiliation Colorado State University Department of Biomedical Sciences, Foothills Campus, Fort Collins, CO 80523, United States of America
⨯
Christopher Fox,

Affiliation Infectious Disease Research Institute, 1616 Eastlake Ave E., Seattle, WA 98103, United States of America
⨯
Richard A. Bowen,

Affiliation Colorado State University Department of Biomedical Sciences, Foothills Campus, Fort Collins, CO 80523, United States of America
⨯
David E. Clements,

Affiliation Hawaii Biotech Inc. 99-193 Aiea Heights Drive, Aiea, Hawaii 96701, United States of America
⨯
Timothy Martyak,

Affiliation Hawaii Biotech Inc. 99-193 Aiea Heights Drive, Aiea, Hawaii 96701, United States of America
⨯
D. Elliot Parks,

Affiliation Hawaii Biotech Inc. 99-193 Aiea Heights Drive, Aiea, Hawaii 96701, United States of America
⨯
Susan Baldwin,

Affiliation Infectious Disease Research Institute, 1616 Eastlake Ave E., Seattle, WA 98103, United States of America
⨯
Steven G. Reed,

Affiliation Infectious Disease Research Institute, 1616 Eastlake Ave E., Seattle, WA 98103, United States of America
⨯
Rhea N. Coler

Affiliation Infectious Disease Research Institute, 1616 Eastlake Ave E., Seattle, WA 98103, United States of America
⨯

A Novel Synthetic TLR-4 Agonist Adjuvant Increases the Protective Response to a Clinical-Stage West Nile Virus Vaccine Antigen in Multiple Formulations

Neal Van Hoeven,
Sharvari Waghmare Joshi,
Ghislain Ismael Nana,
Angela Bosco-Lauth,
Christopher Fox,
Richard A. Bowen,
David E. Clements,
Timothy Martyak,
D. Elliot Parks,
Susan Baldwin

Published: February 22, 2016
https://doi.org/10.1371/journal.pone.0149610

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