Impaired Autophagy in Adult Bone Marrow CD34+ Cells of Patients with Aplastic Anemia: Possible Pathogenic Significance

Jinbo Huang; Meili Ge; Shihong Lu; Jun Shi; Wei Yu; Xingxin Li; Min Wang; Jizhou Zhang; Sizhou Feng; Shuxu Dong; Xuelian Cheng; Yizhou Zheng

doi:10.1371/journal.pone.0149586

Loading metrics

Open Access

Peer-reviewed

Research Article

Impaired Autophagy in Adult Bone Marrow CD34⁺ Cells of Patients with Aplastic Anemia: Possible Pathogenic Significance

Jinbo Huang,

Affiliation State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, P.R. China
⨯
Meili Ge,

Affiliation State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, P.R. China
⨯
Shihong Lu,

Affiliation State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, P.R. China
⨯
Jun Shi,

Affiliation State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, P.R. China
⨯
Wei Yu,

Affiliation State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, P.R. China
⨯
Xingxin Li,

Affiliation State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, P.R. China
⨯
Min Wang,

Affiliation State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, P.R. China
⨯
Jizhou Zhang,

Affiliation State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, P.R. China
⨯
Sizhou Feng,

Affiliation State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, P.R. China
⨯
Shuxu Dong,

Affiliation State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, P.R. China
⨯
Xuelian Cheng,

Affiliation State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, P.R. China
⨯
Yizhou Zheng

* E-mail: zheng_yizhou@hotmail.com

Affiliation State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, P.R. China
⨯

Impaired Autophagy in Adult Bone Marrow CD34⁺ Cells of Patients with Aplastic Anemia: Possible Pathogenic Significance

Jinbo Huang,
Meili Ge,
Shihong Lu,
Jun Shi,
Wei Yu,
Xingxin Li,
Min Wang,
Jizhou Zhang,
Sizhou Feng,
Shuxu Dong

Published: March 1, 2016
https://doi.org/10.1371/journal.pone.0149586

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Autophagic cell death
Is the Subject Area "Autophagic cell death" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Bone marrow cells
Is the Subject Area "Bone marrow cells" applicable to this article?

Thanks for your feedback.
Stem cells
Is the Subject Area "Stem cells" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Neutrophils
Is the Subject Area "Neutrophils" applicable to this article?

Thanks for your feedback.
Confocal microscopy
Is the Subject Area "Confocal microscopy" applicable to this article?

Thanks for your feedback.
Lymphocytes
Is the Subject Area "Lymphocytes" applicable to this article?

Thanks for your feedback.