T47D Cells Expressing Myeloperoxidase Are Able to Process, Traffic and Store the Mature Protein in Lysosomes: Studies in T47D Cells Reveal a Role for Cys319 in MPO Biosynthesis that Precedes Its Known Role in Inter-Molecular Disulfide Bond Formation

Open Access

Peer-reviewed

Research Article

T47D Cells Expressing Myeloperoxidase Are Able to Process, Traffic and Store the Mature Protein in Lysosomes: Studies in T47D Cells Reveal a Role for Cys³¹⁹ in MPO Biosynthesis that Precedes Its Known Role in Inter-Molecular Disulfide Bond Formation

Richard P. Laura,

Affiliation Torrey Pines Pharmaceuticals, Del Mar, California, United States of America
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David Dong,

Affiliation Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, California, United States of America
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Wanda F. Reynolds,

Affiliation Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, California, United States of America
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Richard A. Maki

* E-mail: rmaki@sbpdiscovery.org

Affiliations Torrey Pines Pharmaceuticals, Del Mar, California, United States of America, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, California, United States of America
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HL60 cells
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Lysosomes
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Enzyme-linked immunoassays
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Disulfide bonds
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Immunoprecipitation
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Immunoblotting
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Cysteine
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Peroxidases
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