Ex Vivo and In Vivo Imaging and Biodistribution of Aptamers Targeting the Human Matrix MetalloProtease-9 in Melanomas

David Kryza; Frédéric Debordeaux; Laurent Azéma; Aref Hassan; Olivier Paurelle; Jürgen Schulz; Catherine Savona-Baron; Elsa Charignon; Pauline Bonazza; Jacqueline Taleb; Philippe Fernandez; Marc Janier; Jean Jacques Toulmé

doi:10.1371/journal.pone.0149387

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Peer-reviewed

Research Article

Ex Vivo and In Vivo Imaging and Biodistribution of Aptamers Targeting the Human Matrix MetalloProtease-9 in Melanomas

David Kryza ,

* E-mail: david.kryza@chu-lyon.fr

Affiliations UNIV Lyon, Université Claude Bernard Lyon 1, LAGEP UMR 5007 CNRS, Villeurbanne, France, Hospices Civils de Lyon, Imthernat plateform, Lyon, France
⨯
Frédéric Debordeaux,

Affiliations Université de Bordeaux, CNRS, INCIA, UMR 5287, Bordeaux, France, Service de Médecine Nucléaire, CHU de Bordeaux, Bordeaux, France
⨯
Laurent Azéma,

Affiliations Inserm U1212, Bordeaux, France, CNRS UMR5320, Pessac, France, University of Bordeaux, ARNA Laboratory, Bordeaux, France
⨯
Aref Hassan,

Affiliations Inserm U1212, Bordeaux, France, CNRS UMR5320, Pessac, France, University of Bordeaux, ARNA Laboratory, Bordeaux, France
⨯
Olivier Paurelle,

Affiliations Inserm U1212, Bordeaux, France, CNRS UMR5320, Pessac, France, University of Bordeaux, ARNA Laboratory, Bordeaux, France
⨯
Jürgen Schulz,

Affiliations Université de Bordeaux, CNRS, INCIA, UMR 5287, Bordeaux, France, Service de Médecine Nucléaire, CHU de Bordeaux, Bordeaux, France
⨯
Catherine Savona-Baron,

Affiliation Université de Bordeaux, CNRS, INCIA, UMR 5287, Bordeaux, France
⨯
Elsa Charignon,

Affiliation Hospices Civils de Lyon, Imthernat plateform, Lyon, France
⨯
Pauline Bonazza,

Affiliation Hospices Civils de Lyon, Imthernat plateform, Lyon, France
⨯
Jacqueline Taleb,

Affiliation UNIV Lyon, Université Claude Bernard Lyon 1, LAGEP UMR 5007 CNRS, Villeurbanne, France
⨯
Philippe Fernandez,

Affiliations Université de Bordeaux, CNRS, INCIA, UMR 5287, Bordeaux, France, Service de Médecine Nucléaire, CHU de Bordeaux, Bordeaux, France
⨯
Marc Janier ,

¶‡ MJ and JJT are co-directors of this work.

Affiliations UNIV Lyon, Université Claude Bernard Lyon 1, LAGEP UMR 5007 CNRS, Villeurbanne, France, Hospices Civils de Lyon, Imthernat plateform, Lyon, France
⨯
Jean Jacques Toulmé

¶‡ MJ and JJT are co-directors of this work.

Affiliations Inserm U1212, Bordeaux, France, CNRS UMR5320, Pessac, France, University of Bordeaux, ARNA Laboratory, Bordeaux, France
⨯

Ex Vivo and In Vivo Imaging and Biodistribution of Aptamers Targeting the Human Matrix MetalloProtease-9 in Melanomas

David Kryza,
Frédéric Debordeaux,
Laurent Azéma,
Aref Hassan,
Olivier Paurelle,
Jürgen Schulz,
Catherine Savona-Baron,
Elsa Charignon,
Pauline Bonazza,
Jacqueline Taleb

Published: February 22, 2016
https://doi.org/10.1371/journal.pone.0149387

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