Blockade of Hedgehog Signaling Synergistically Increases Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cell Lines

Xiao-Yan Bai; Xu-Chao Zhang; Su-Qing Yang; She-Juan An; Zhi-Hong Chen; Jian Su; Zhi Xie; Lan-Ying Gou; Yi-Long Wu

doi:10.1371/journal.pone.0149370

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Open Access

Peer-reviewed

Research Article

Blockade of Hedgehog Signaling Synergistically Increases Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cell Lines

Xiao-Yan Bai,

Affiliation Department of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Science, Guangzhou 510080, China
⨯
Xu-Chao Zhang,

Affiliation Department of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Science, Guangzhou 510080, China
⨯
Su-Qing Yang,

Affiliation Department of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Science, Guangzhou 510080, China
⨯
She-Juan An,

Affiliation Department of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Science, Guangzhou 510080, China
⨯
Zhi-Hong Chen,

Affiliation Department of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Science, Guangzhou 510080, China
⨯
Jian Su,

Affiliation Department of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Science, Guangzhou 510080, China
⨯
Zhi Xie,

Affiliation Department of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Science, Guangzhou 510080, China
⨯
Lan-Ying Gou,

Affiliations Department of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Science, Guangzhou 510080, China, Southern Medical University, Guangzhou 510515, China
⨯
Yi-Long Wu

* E-mail: syylwu@live.cn

Affiliation Department of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Science, Guangzhou 510080, China
⨯

Blockade of Hedgehog Signaling Synergistically Increases Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cell Lines

Xiao-Yan Bai,
Xu-Chao Zhang,
Su-Qing Yang,
She-Juan An,
Zhi-Hong Chen,
Jian Su,
Zhi Xie,
Lan-Ying Gou,
Yi-Long Wu

Published: March 4, 2016
https://doi.org/10.1371/journal.pone.0149370

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Hedgehog signaling
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Non-small cell lung cancer
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