SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids

Takamasa Tobita; Jorge Guzman-Lepe; Kazuki Takeishi; Toshimasa Nakao; Yang Wang; Fanying Meng; Chu-Xia Deng; Alexandra Collin de l’Hortet; Alejandro Soto-Gutierrez

doi:10.1371/journal.pone.0149344

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Peer-reviewed

Research Article

SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids

Takamasa Tobita,

Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Jorge Guzman-Lepe,

Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Kazuki Takeishi,

Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Toshimasa Nakao,

Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Yang Wang,

Affiliations Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing, China
⨯
Fanying Meng,

Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Chu-Xia Deng,

Affiliation Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, China
⨯
Alexandra Collin de l’Hortet ,

* E-mail: alexandra.collin@pitt.edu (ACH); sotogutierreza@upmc.edu (ASG);

Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Alejandro Soto-Gutierrez

* E-mail: alexandra.collin@pitt.edu (ACH); sotogutierreza@upmc.edu (ASG);

Affiliations Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Thomas E Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, McGowan Institute for Regenerative Medicine; Pittsburgh, Pennsylvania, United States of America
⨯

SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids

Takamasa Tobita,
Jorge Guzman-Lepe,
Kazuki Takeishi,
Toshimasa Nakao,
Yang Wang,
Fanying Meng,
Chu-Xia Deng,
Alexandra Collin de l’Hortet,
Alejandro Soto-Gutierrez

Published: February 18, 2016
https://doi.org/10.1371/journal.pone.0149344

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Hepatocytes
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Fatty liver
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Glucose
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Lipogenesis
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Lipid metabolism
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Steatosis
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