Alternative Pathway Inhibition by Exogenous Factor H Fails to Attenuate Inflammation and Vascular Leakage in Experimental Pneumococcal Sepsis in Mice

Erika van der Maten; Saskia van Selm; Jeroen D. Langereis; Hester J. Bootsma; Fred J. H. van Opzeeland; Ronald de Groot; Marien I. de Jonge; Michiel van der Flier

doi:10.1371/journal.pone.0149307

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Open Access

Peer-reviewed

Research Article

Alternative Pathway Inhibition by Exogenous Factor H Fails to Attenuate Inflammation and Vascular Leakage in Experimental Pneumococcal Sepsis in Mice

Erika van der Maten,

Affiliation Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands
⨯
Saskia van Selm,

Affiliation Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands
⨯
Jeroen D. Langereis,

Affiliation Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands
⨯
Hester J. Bootsma,

Current address: Laboratory for Infectious Diseases and Screening, Centre for Infectious Disease Control, RIVM, Bilthoven, The Netherlands

Affiliation Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands
⨯
Fred J. H. van Opzeeland,

Affiliation Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands
⨯
Ronald de Groot,

Affiliation Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands
⨯
Marien I. de Jonge,

Affiliation Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands
⨯
Michiel van der Flier

* E-mail: Michiel.vanderFlier@radboudumc.nl

Affiliations Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands, Pediatric Infectious Diseases and Immunology, Department of Pediatrics, Radboudumc, Nijmegen, The Netherlands
⨯

Alternative Pathway Inhibition by Exogenous Factor H Fails to Attenuate Inflammation and Vascular Leakage in Experimental Pneumococcal Sepsis in Mice

Erika van der Maten,
Saskia van Selm,
Jeroen D. Langereis,
Hester J. Bootsma,
Fred J. H. van Opzeeland,
Ronald de Groot,
Marien I. de Jonge,
Michiel van der Flier

Published: February 12, 2016
https://doi.org/10.1371/journal.pone.0149307

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Sepsis
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