Release of Matrix Metalloproteinases-2 and 9 by S-Nitrosylated Caveolin-1 Contributes to Degradation of Extracellular Matrix in tPA-Treated Hypoxic Endothelial Cells

Haoming Song; Youjun Cheng; Gang Bi; Yihui Zhu; Wei Jun; Wenlin Ma; Huimin Wu

doi:10.1371/journal.pone.0149269

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Peer-reviewed

Research Article

Release of Matrix Metalloproteinases-2 and 9 by S-Nitrosylated Caveolin-1 Contributes to Degradation of Extracellular Matrix in tPA-Treated Hypoxic Endothelial Cells

Haoming Song ,

Contributed equally to this work with: Haoming Song, Youjun Cheng

* E-mail: mawenlin@medmail.com.cn (WM); 13621720055@139.com (HW); songhao-ming@163.com (HS)

Affiliation Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China
⨯
Youjun Cheng ,

Contributed equally to this work with: Haoming Song, Youjun Cheng

Affiliation Department of Neurology, Guangzhou Brain Hospital, Affiliated Hospital of Guangzhou Medical University, Guangzhou 510370, China
⨯
Gang Bi,

Affiliations Translational Center for Stem Cell Research, Tongji Hospital, Stem Cell Research Center, Tongji University School of Medicine, Shanghai 200065, China, Department of orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China
⨯
Yihui Zhu,

Affiliation Translational Center for Stem Cell Research, Tongji Hospital, Stem Cell Research Center, Tongji University School of Medicine, Shanghai 200065, China
⨯
Wei Jun,

Affiliations Translational Center for Stem Cell Research, Tongji Hospital, Stem Cell Research Center, Tongji University School of Medicine, Shanghai 200065, China, Department of general surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China
⨯
Wenlin Ma ,

* E-mail: mawenlin@medmail.com.cn (WM); 13621720055@139.com (HW); songhao-ming@163.com (HS)

Affiliations Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China, Translational Center for Stem Cell Research, Tongji Hospital, Stem Cell Research Center, Tongji University School of Medicine, Shanghai 200065, China
⨯
Huimin Wu

* E-mail: mawenlin@medmail.com.cn (WM); 13621720055@139.com (HW); songhao-ming@163.com (HS)

Affiliations Translational Center for Stem Cell Research, Tongji Hospital, Stem Cell Research Center, Tongji University School of Medicine, Shanghai 200065, China, Department of general surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China
⨯

Release of Matrix Metalloproteinases-2 and 9 by S-Nitrosylated Caveolin-1 Contributes to Degradation of Extracellular Matrix in tPA-Treated Hypoxic Endothelial Cells

Haoming Song,
Youjun Cheng,
Gang Bi,
Yihui Zhu,
Wei Jun,
Wenlin Ma,
Huimin Wu

Published: February 16, 2016
https://doi.org/10.1371/journal.pone.0149269

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Secretion
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S-nitrosylation
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Endothelial cells
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Extracellular matrix
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