Poor Long-Term Efficacy of Prevnar-13 in Sickle Cell Disease Mice Is Associated with an Inability to Sustain Pneumococcal-Specific Antibody Titers

Steven M. Szczepanek; Sean Roberts; Kara Rogers; Christina Cotte; Alexander J. Adami; Sonali J. Bracken; Sharon Salmon; Eric R. Secor Jr.; Roger S. Thrall; Biree Andemariam; Dennis W. Metzger

doi:10.1371/journal.pone.0149261

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Open Access

Peer-reviewed

Research Article

Poor Long-Term Efficacy of Prevnar-13 in Sickle Cell Disease Mice Is Associated with an Inability to Sustain Pneumococcal-Specific Antibody Titers

Steven M. Szczepanek ,

Contributed equally to this work with: Steven M. Szczepanek, Sean Roberts

* E-mail: steven.szczepanek@uconn.edu

Affiliation Center of Excellence for Vaccine Research, Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT, United States of America, 06269
⨯
Sean Roberts ,

Contributed equally to this work with: Steven M. Szczepanek, Sean Roberts

Affiliation Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY, United States of America, 12208
⨯
Kara Rogers,

Affiliation Center of Excellence for Vaccine Research, Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT, United States of America, 06269
⨯
Christina Cotte,

Affiliation Center of Excellence for Vaccine Research, Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT, United States of America, 06269
⨯
Alexander J. Adami,

Affiliation Department of Immunology, University of Connecticut Health Center, Farmington, CT, United States of America, 06030
⨯
Sonali J. Bracken,

Affiliation Department of Immunology, University of Connecticut Health Center, Farmington, CT, United States of America, 06030
⨯
Sharon Salmon,

Affiliation Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY, United States of America, 12208
⨯
Eric R. Secor Jr.,

Affiliation Helen and Harry Gray Cancer Center and Department of Medicine, Division of Integrative Medicine, Hartford Hospital, Hartford, CT, United States of America, 06106
⨯
Roger S. Thrall,

Affiliation Department of Immunology, University of Connecticut Health Center, Farmington, CT, United States of America, 06030
⨯
Biree Andemariam,

Affiliation The Lea’s Foundation Center for Hematological Disorders, Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, CT, United States of America, 06030
⨯
Dennis W. Metzger

Affiliation Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY, United States of America, 12208
⨯

Poor Long-Term Efficacy of Prevnar-13 in Sickle Cell Disease Mice Is Associated with an Inability to Sustain Pneumococcal-Specific Antibody Titers

Steven M. Szczepanek,
Sean Roberts,
Kara Rogers,
Christina Cotte,
Alexander J. Adami,
Sonali J. Bracken,
Sharon Salmon,
Eric R. Secor Jr.,
Roger S. Thrall,
Biree Andemariam

Published: February 24, 2016
https://doi.org/10.1371/journal.pone.0149261

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29 Dec 2016
15:39 GMT
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Functional Antibody Responses Persist 1 Year after Immunization with 2 Doses of 13-Valent Pneumococcal Conjugate Vaccine in Infants with Sickle Cell Disease Posted by mdemontalembert on 16 Dec 2016 at 21:53 GMT

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