Impaired Inactivation of L-Type Ca²⁺ Current as a Potential Mechanism for Variable Arrhythmogenic Liability of HERG K⁺ Channel Blocking Drugs

• Jae Gon Kim ,

  ¶‡ These authors are joint co-first authors on this work.

  Affiliations Department of Physiology and the Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, South Korea, Next-Generation Pharmaceutical Research Center, Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, Daejeon, South Korea

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• Dong Jun Sung ,

  ¶‡ These authors are joint co-first authors on this work.

  Affiliation Division of Sport Science, College of Science and Technology, Konkuk University, Choongju, South Korea

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• Hyun-ji Kim ,

  ¶‡ These authors are joint co-first authors on this work.

  Affiliation Department of Physiology and the Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, South Korea

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• Sang Woong Park,

  Affiliation Department of Physiology, KU Open Innovation Center, Research Institute of Medical Science, Konkuk University School of Medicine, Chungju, South Korea

  ⨯
• Kyung Jong Won,

  Affiliation Department of Physiology, KU Open Innovation Center, Research Institute of Medical Science, Konkuk University School of Medicine, Chungju, South Korea

  ⨯
• Bokyung Kim,

  Affiliation Department of Physiology, KU Open Innovation Center, Research Institute of Medical Science, Konkuk University School of Medicine, Chungju, South Korea

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• Ho Chul Shin,

  Affiliation Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Konkuk University, Seoul, South Korea

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• Ki-Suk Kim,

  Affiliations Next-Generation Pharmaceutical Research Center, Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, Daejeon, South Korea, Human and Environmental Toxicology Program, University of Science and Technology, Daejeon, South Korea

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• Chae Hun Leem,

  Affiliation Department of Physiology, University of Ulsan College of Medicine, Seoul, South Korea

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• Yin Hua Zhang,

  Affiliation Department of Physiology, Seoul National University College of Medicine, Seoul, South Korea

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• Hana Cho ,

  * E-mail: hanacho@skku.edu; ymbae30@kku.ac.kr

  Affiliation Department of Physiology and the Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, South Korea

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• Young Min Bae

  * E-mail: hanacho@skku.edu; ymbae30@kku.ac.kr

  Affiliation Department of Physiology, KU Open Innovation Center, Research Institute of Medical Science, Konkuk University School of Medicine, Chungju, South Korea

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