Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NFκB and Autophagy Dependent Bacillary Killing

Ciaran Lawlor; Gemma O’Connor; Seonadh O’Leary; Paul J. Gallagher; Sally-Ann Cryan; Joseph Keane; Mary P. O’Sullivan

doi:10.1371/journal.pone.0149167

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Peer-reviewed

Research Article

Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NFκB and Autophagy Dependent Bacillary Killing

Ciaran Lawlor,

Current address: Moderna Therapeutics, Cambridge, Massachusetts, United States of America

Affiliations School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland, Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, and St. James’ Hospital, Dublin, Ireland
⨯
Gemma O’Connor,

Affiliations School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland, Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, and St. James’ Hospital, Dublin, Ireland
⨯
Seonadh O’Leary,

Affiliation Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, and St. James’ Hospital, Dublin, Ireland
⨯
Paul J. Gallagher,

Affiliation School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland
⨯
Sally-Ann Cryan ,

Contributed equally to this work with: Sally-Ann Cryan, Joseph Keane, Mary P. O’Sullivan

Affiliations School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland, Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Ireland
⨯
Joseph Keane ,

Contributed equally to this work with: Sally-Ann Cryan, Joseph Keane, Mary P. O’Sullivan

Affiliation Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, and St. James’ Hospital, Dublin, Ireland
⨯
Mary P. O’Sullivan

Contributed equally to this work with: Sally-Ann Cryan, Joseph Keane, Mary P. O’Sullivan

* E-mail: mary.osullivan@tcd.ie

Affiliation Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, and St. James’ Hospital, Dublin, Ireland
⨯

Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NFκB and Autophagy Dependent Bacillary Killing

Ciaran Lawlor,
Gemma O’Connor,
Seonadh O’Leary,
Paul J. Gallagher,
Sally-Ann Cryan,
Joseph Keane,
Mary P. O’Sullivan

Published: February 19, 2016
https://doi.org/10.1371/journal.pone.0149167

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Macrophages
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Mycobacterium tuberculosis
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Autophagic cell death
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