Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension

Qian Li; Min Mao; Yanli Qiu; Gaofeng Liu; Tingting Sheng; Xiufeng Yu; Shuang Wang; Daling Zhu

doi:10.1371/journal.pone.0149164

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Peer-reviewed

Research Article

Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension

Qian Li ,

Contributed equally to this work with: Qian Li, Min Mao

Affiliations Department of Pharmaceutical Analysis, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang Province, China, Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
⨯
Min Mao ,

Contributed equally to this work with: Qian Li, Min Mao

Affiliations Department of Pathophysiology, Harbin Medical University-Daqing, Daqing, Heilongjiang Province, China, Bio-pharmaceutical Key Laboratory of Harbin, Harbin Medical University, Harbin, Heilongjiang Province, China
⨯
Yanli Qiu,

Affiliation Department of Pharmaceutical Analysis, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang Province, China
⨯
Gaofeng Liu,

Affiliation Department of Pharmacy, the Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang Province, China
⨯
Tingting Sheng,

Affiliation Department of Pathophysiology, Harbin Medical University-Daqing, Daqing, Heilongjiang Province, China
⨯
Xiufeng Yu,

Affiliation Department of Pathophysiology, Harbin Medical University-Daqing, Daqing, Heilongjiang Province, China
⨯
Shuang Wang,

Affiliation Department of Pharmaceutical Analysis, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang Province, China
⨯
Daling Zhu

* E-mail: liqian@ems.hrbmu.edu.cn

Affiliations Department of Pathophysiology, Harbin Medical University-Daqing, Daqing, Heilongjiang Province, China, Bio-pharmaceutical Key Laboratory of Harbin, Harbin Medical University, Harbin, Heilongjiang Province, China
⨯

Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension

Qian Li,
Min Mao,
Yanli Qiu,
Gaofeng Liu,
Tingting Sheng,
Xiufeng Yu,
Shuang Wang,
Daling Zhu

Published: February 12, 2016
https://doi.org/10.1371/journal.pone.0149164

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