Exome Sequencing in Classic Hairy Cell Leukaemia Reveals Widespread Variation in Acquired Somatic Mutations between Individual Tumours Apart from the Signature BRAF V(600)E Lesion

Nicola J. Weston-Bell; Will Tapper; Jane Gibson; Dean Bryant; Yurany Moreno; Melford John; Sarah Ennis; Hanneke C. Kluin-Nelemans; Andrew R. Collins; Surinder S. Sahota

doi:10.1371/journal.pone.0149162

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Peer-reviewed

Research Article

Exome Sequencing in Classic Hairy Cell Leukaemia Reveals Widespread Variation in Acquired Somatic Mutations between Individual Tumours Apart from the Signature BRAF V(600)E Lesion

Nicola J. Weston-Bell ,

¶‡ These authors are joint first authors on this work.

Affiliation Tumour Immunogenetics Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Will Tapper ,

¶‡ These authors are joint first authors on this work.

Affiliation Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Jane Gibson,

Affiliation Centre for Biological Sciences, Faculty of Natural and Environmental Studies, University of Southampton, Southampton, United Kingdom
⨯
Dean Bryant,

Affiliation Tumour Immunogenetics Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Yurany Moreno,

Affiliation Tumour Immunogenetics Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Melford John,

Affiliation Department of Preclinical Sciences, Faculty of Medical Sciences, University of The West Indies, St. Augustine, Trinidad and Tobago
⨯
Sarah Ennis,

Affiliation Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Hanneke C. Kluin-Nelemans,

Affiliation Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
⨯
Andrew R. Collins,

Affiliation Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Surinder S. Sahota

* E-mail: s.s.sahota@soton.ac.uk

Affiliation Tumour Immunogenetics Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯

Exome Sequencing in Classic Hairy Cell Leukaemia Reveals Widespread Variation in Acquired Somatic Mutations between Individual Tumours Apart from the Signature BRAF V(600)E Lesion

Nicola J. Weston-Bell,
Will Tapper,
Jane Gibson,
Dean Bryant,
Yurany Moreno,
Melford John,
Sarah Ennis,
Hanneke C. Kluin-Nelemans,
Andrew R. Collins,
Surinder S. Sahota

Published: February 12, 2016
https://doi.org/10.1371/journal.pone.0149162

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