Integration of Stem Cell to Chondrocyte-Derived Cartilage Matrix in Healthy and Osteoarthritic States in the Presence of Hydroxyapatite Nanoparticles

Rupak Dua; Kristin Comella; Ryan Butler; Glenda Castellanos; Bryn Brazille; Andrew Claude; Arvind Agarwal; Jun Liao; Sharan Ramaswamy

doi:10.1371/journal.pone.0149121

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Open Access

Peer-reviewed

Research Article

Integration of Stem Cell to Chondrocyte-Derived Cartilage Matrix in Healthy and Osteoarthritic States in the Presence of Hydroxyapatite Nanoparticles

Rupak Dua,

Affiliation Tissue Engineered Mechanics, Imaging and Materials Laboratory (TEMIM Lab), Department of Biomedical Engineering, Florida International University, Miami, Florida, 33174, United States of America
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Kristin Comella,

Affiliation Tissue Engineered Mechanics, Imaging and Materials Laboratory (TEMIM Lab), Department of Biomedical Engineering, Florida International University, Miami, Florida, 33174, United States of America
⨯
Ryan Butler,

Affiliation College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi, 39762, United States of America
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Glenda Castellanos,

Affiliation Tissue Engineered Mechanics, Imaging and Materials Laboratory (TEMIM Lab), Department of Biomedical Engineering, Florida International University, Miami, Florida, 33174, United States of America
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Bryn Brazille,

Affiliation Tissue Bioengineering Laboratory, Department of Agricultural & Biological Engineering, Mississippi State University, Starkville, Mississippi, 39762, United States of America
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Andrew Claude,

Affiliation College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi, 39762, United States of America
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Arvind Agarwal,

Affiliation Advanced Materials Engineering Research Institute (AMERI), Department of Mechanical and Materials Engineering, Florida International University, Miami, Florida, 33174, United States of America
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Jun Liao,

Affiliation Tissue Bioengineering Laboratory, Department of Agricultural & Biological Engineering, Mississippi State University, Starkville, Mississippi, 39762, United States of America
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Sharan Ramaswamy

* E-mail: sramaswa@fiu.edu

Affiliation Tissue Engineered Mechanics, Imaging and Materials Laboratory (TEMIM Lab), Department of Biomedical Engineering, Florida International University, Miami, Florida, 33174, United States of America
⨯

Integration of Stem Cell to Chondrocyte-Derived Cartilage Matrix in Healthy and Osteoarthritic States in the Presence of Hydroxyapatite Nanoparticles

Rupak Dua,
Kristin Comella,
Ryan Butler,
Glenda Castellanos,
Bryn Brazille,
Andrew Claude,
Arvind Agarwal,
Jun Liao,
Sharan Ramaswamy

Published: February 12, 2016
https://doi.org/10.1371/journal.pone.0149121

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Cartilage
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Osteoarthritis
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Extracellular matrix
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Collagens
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Chondrocytes
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Articular cartilage
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