CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

Sara Costa-Cabral; Rachel Brough; Asha Konde; Marieke Aarts; James Campbell; Eliana Marinari; Jenna Riffell; Alberto Bardelli; Christopher Torrance; Christopher J. Lord; Alan Ashworth

doi:10.1371/journal.pone.0149099

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Open Access

Peer-reviewed

Research Article

CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

Sara Costa-Cabral,

Affiliations The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, United Kingdom, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, United Kingdom
⨯
Rachel Brough,

Affiliations The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, United Kingdom, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, United Kingdom
⨯
Asha Konde,

Affiliations The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, United Kingdom, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, United Kingdom
⨯
Marieke Aarts,

Affiliations The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, United Kingdom, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, United Kingdom
⨯
James Campbell,

Affiliations The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, United Kingdom, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, United Kingdom
⨯
Eliana Marinari,

Affiliations The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, United Kingdom, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, United Kingdom
⨯
Jenna Riffell,

Affiliations The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, United Kingdom, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, United Kingdom
⨯
Alberto Bardelli,

Affiliation IFOM—FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy
⨯
Christopher Torrance,

Current address: PhoreMost, 23 Cambridge Science Park, Milton Road, Cambridge, CB4 0EY, United Kingdom

Affiliation Horizon Discovery, 7100 Cambridge Research Park, Waterbeach, Cambridge, CB25 9TL, United Kingdom
⨯
Christopher J. Lord ,

* E-mail: Chris.Lord@icr.ac.uk

Affiliations The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, United Kingdom, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, United Kingdom
⨯
Alan Ashworth

Current address: UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, 94158, United States of America

Affiliations The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, SW3 6JB, United Kingdom, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, United Kingdom
⨯

CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

Sara Costa-Cabral,
Rachel Brough,
Asha Konde,
Marieke Aarts,
James Campbell,
Eliana Marinari,
Jenna Riffell,
Alberto Bardelli,
Christopher Torrance,
Christopher J. Lord

Published: February 16, 2016
https://doi.org/10.1371/journal.pone.0149099

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04 Mar 2016
18:17 GMT
Most Recent

Correction to supplementary Table 1 Posted by lordc on 04 Mar 2016 at 18:17 GMT

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