Factor Xa Inhibitor Suppresses the Release of Phosphorylated HSP27 from Collagen-Stimulated Human Platelets: Inhibition of HSP27 Phosphorylation via p44/p42 MAP Kinase

Masanori Tsujimoto; Gen Kuroyanagi; Rie Matsushima-Nishiwaki; Yuko Kito; Yukiko Enomoto; Hiroki Iida; Shinji Ogura; Takanobu Otsuka; Haruhiko Tokuda; Osamu Kozawa; Toru Iwama

doi:10.1371/journal.pone.0149077

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Peer-reviewed

Research Article

Factor Xa Inhibitor Suppresses the Release of Phosphorylated HSP27 from Collagen-Stimulated Human Platelets: Inhibition of HSP27 Phosphorylation via p44/p42 MAP Kinase

Masanori Tsujimoto,

Affiliations Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan, Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Gen Kuroyanagi,

Affiliations Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan, Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
⨯
Rie Matsushima-Nishiwaki,

Affiliation Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Yuko Kito,

Affiliation Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Yukiko Enomoto,

Affiliation Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Hiroki Iida,

Affiliation Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Shinji Ogura,

Affiliation Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Takanobu Otsuka,

Affiliation Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
⨯
Haruhiko Tokuda,

Affiliations Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan, Department of Clinical Laboratory, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
⨯
Osamu Kozawa ,

* E-mail: okozawa@gifu-u.ac.jp

Affiliation Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Toru Iwama

Affiliation Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan
⨯

Factor Xa Inhibitor Suppresses the Release of Phosphorylated HSP27 from Collagen-Stimulated Human Platelets: Inhibition of HSP27 Phosphorylation via p44/p42 MAP Kinase

Masanori Tsujimoto,
Gen Kuroyanagi,
Rie Matsushima-Nishiwaki,
Yuko Kito,
Yukiko Enomoto,
Hiroki Iida,
Shinji Ogura,
Takanobu Otsuka,
Haruhiko Tokuda,
Osamu Kozawa

Published: February 11, 2016
https://doi.org/10.1371/journal.pone.0149077

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