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Open Access

Peer-reviewed

Research Article

Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages

Aravind Tallam,

Current address: TWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung, Hannover, Germany

Affiliation Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg
⨯
Thaneer M. Perumal,

Current Address: Sage Bionetworks, Seattle, Washington, United States of America

Affiliation Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg
⨯
Paul M. Antony,

Affiliation Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg
⨯
Christian Jäger,

Affiliation Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg
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Joëlle V. Fritz,

Affiliation Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg
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Laurent Vallar,

Affiliation Genomics Research Laboratory, Luxembourg Institute of Health, Luxembourg, Luxembourg
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Rudi Balling,

Affiliation Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg
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Antonio del Sol ,

* E-mail: antonio.delsol@uni.lu (AdS); alessandro.michelucci@lih.lu (AM)

¶‡ AdS and AM are Joint Senior Authors.

Affiliation Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg
⨯
Alessandro Michelucci

* E-mail: antonio.delsol@uni.lu (AdS); alessandro.michelucci@lih.lu (AM)

¶‡ AdS and AM are Joint Senior Authors.

Affiliations Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg, NORLUX Neuro-Oncology Laboratory, Luxembourg Institute of Health, Luxembourg, Luxembourg
⨯

Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages

Aravind Tallam,
Thaneer M. Perumal,
Paul M. Antony,
Christian Jäger,
Joëlle V. Fritz,
Laurent Vallar,
Rudi Balling,
Antonio del Sol,
Alessandro Michelucci

x

Published: February 12, 2016
https://doi.org/10.1371/journal.pone.0149050

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Macrophages
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Transcriptional control
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Small interfering RNA
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Regulator genes
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Transcription factors
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Gene expression
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Gene regulation
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Mitochondria
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