Depression of Complement Regulatory Factors in Rat and Human Renal Grafts Is Associated with the Progress of Acute T-Cell Mediated Rejection

Kazuaki Yamanaka; Yoichi Kakuta; Shuji Miyagawa; Shigeaki Nakazawa; Taigo Kato; Toyofumi Abe; Ryoichi Imamura; Masayoshi Okumi; Akira Maeda; Hiroomi Okuyama; Masashi Mizuno; Norio Nonomura

doi:10.1371/journal.pone.0148881

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Open Access

Peer-reviewed

Research Article

Depression of Complement Regulatory Factors in Rat and Human Renal Grafts Is Associated with the Progress of Acute T-Cell Mediated Rejection

Kazuaki Yamanaka,

Affiliation Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Yoichi Kakuta ,

* E-mail: kakuta@uro.med.osaka-u.ac.jp (YK); miyagawa@orgtrp.med.osaka-u.ac.jp (SM)

Affiliation Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Shuji Miyagawa ,

* E-mail: kakuta@uro.med.osaka-u.ac.jp (YK); miyagawa@orgtrp.med.osaka-u.ac.jp (SM)

Affiliation Division of Organ Transplantation, Department of Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Shigeaki Nakazawa,

Affiliation Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Taigo Kato,

Affiliation Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Toyofumi Abe,

Affiliation Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Ryoichi Imamura,

Affiliation Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Masayoshi Okumi,

Affiliation Department of Urology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan
⨯
Akira Maeda,

Affiliation Division of Organ Transplantation, Department of Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Hiroomi Okuyama,

Affiliation Division of Organ Transplantation, Department of Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Masashi Mizuno,

Affiliation Department of Nephrology and Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
⨯
Norio Nonomura

Affiliation Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯

Depression of Complement Regulatory Factors in Rat and Human Renal Grafts Is Associated with the Progress of Acute T-Cell Mediated Rejection

Kazuaki Yamanaka,
Yoichi Kakuta,
Shuji Miyagawa,
Shigeaki Nakazawa,
Taigo Kato,
Toyofumi Abe,
Ryoichi Imamura,
Masayoshi Okumi,
Akira Maeda,
Hiroomi Okuyama

Published: February 29, 2016
https://doi.org/10.1371/journal.pone.0148881

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Complement system
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Renal transplantation
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Complement activation
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Glomeruli
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Kidneys
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Biopsy
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Complement receptors
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Graft survival
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