Using Gelatin Nanoparticle Mediated Intranasal Delivery of Neuropeptide Substance P to Enhance Neuro-Recovery in Hemiparkinsonian Rats

Ying-Zheng Zhao; Rong-Rong Jin; Wei Yang; Qi Xiang; Wen-Ze Yu; Qian Lin; Fu-Rong Tian; Kai-Li Mao; Chuan-Zhu Lv; Yi-Xiáng J. Wáng; Cui-Tao Lu

doi:10.1371/journal.pone.0148848

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Open Access

Peer-reviewed

Research Article

Using Gelatin Nanoparticle Mediated Intranasal Delivery of Neuropeptide Substance P to Enhance Neuro-Recovery in Hemiparkinsonian Rats

Ying-Zheng Zhao ,

Contributed equally to this work with: Ying-Zheng Zhao, Rong-Rong Jin, Wei Yang

Affiliations College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China, Hainan Medical College, Haikou, Hainan 570102, China
⨯
Rong-Rong Jin ,

Contributed equally to this work with: Ying-Zheng Zhao, Rong-Rong Jin, Wei Yang

Affiliation Taizhou Traditional Chinese Medical Hospital, Taizhou, Zhejiang 318000, China
⨯
Wei Yang ,

Contributed equally to this work with: Ying-Zheng Zhao, Rong-Rong Jin, Wei Yang

Affiliation College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
⨯
Qi Xiang,

Affiliation Biopharmaceutical R&D Center of Jinan University, Guangzhou, Guangdong 510000, China
⨯
Wen-Ze Yu,

Affiliation College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
⨯
Qian Lin,

Affiliation College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
⨯
Fu-Rong Tian,

Affiliation College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
⨯
Kai-Li Mao,

Affiliation College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
⨯
Chuan-Zhu Lv,

Affiliation Hainan Medical College, Haikou, Hainan 570102, China
⨯
Yi-Xiáng J. Wáng ,

* E-mail: yixiang_wang@cuhk.edu.hk (YXW); lctuua@sina.com (CTL)

Affiliation Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SA
⨯
Cui-Tao Lu

* E-mail: yixiang_wang@cuhk.edu.hk (YXW); lctuua@sina.com (CTL)

Affiliations The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
⨯

Using Gelatin Nanoparticle Mediated Intranasal Delivery of Neuropeptide Substance P to Enhance Neuro-Recovery in Hemiparkinsonian Rats

Ying-Zheng Zhao,
Rong-Rong Jin,
Wei Yang,
Qi Xiang,
Wen-Ze Yu,
Qian Lin,
Fu-Rong Tian,
Kai-Li Mao,
Chuan-Zhu Lv,
Yi-Xiáng J. Wáng

Published: February 19, 2016
https://doi.org/10.1371/journal.pone.0148848

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