Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease

Qi Peng; Bin Wu; Mali Jiang; Jing Jin; Zhipeng Hou; Jennifer Zheng; Jiangyang Zhang; Wenzhen Duan

doi:10.1371/journal.pone.0148839

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Peer-reviewed

Research Article

Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease

Qi Peng ,

Contributed equally to this work with: Qi Peng, Bin Wu

Affiliation Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Bin Wu ,

Contributed equally to this work with: Qi Peng, Bin Wu

Affiliations Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of General Practice, The First hospital of China Medical University, Shenyang, Liaoning Province, China
⨯
Mali Jiang,

Affiliation Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Jing Jin,

Affiliation Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Zhipeng Hou,

Affiliation Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Jennifer Zheng,

Affiliation Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Jiangyang Zhang,

Affiliation Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Wenzhen Duan

* E-mail: wduan2@jhmi.edu

Affiliations Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease

Qi Peng,
Bin Wu,
Mali Jiang,
Jing Jin,
Zhipeng Hou,
Jennifer Zheng,
Jiangyang Zhang,
Wenzhen Duan

Published: February 9, 2016
https://doi.org/10.1371/journal.pone.0148839

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