An Orally Active Allosteric GLP-1 Receptor Agonist Is Neuroprotective in Cellular and Rodent Models of Stroke

Huinan Zhang; Yunhan Liu; Shaoyu Guan; Di Qu; Ling Wang; Xinshang Wang; Xubo Li; Shimeng Zhou; Ying Zhou; Ning Wang; Jingru Meng; Xue Ma

doi:10.1371/journal.pone.0148827

Loading metrics

Open Access

Peer-reviewed

Research Article

An Orally Active Allosteric GLP-1 Receptor Agonist Is Neuroprotective in Cellular and Rodent Models of Stroke

Huinan Zhang ,

Contributed equally to this work with: Huinan Zhang, Yunhan Liu, Shaoyu Guan

Affiliation Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi’an, China
⨯
Yunhan Liu ,

Contributed equally to this work with: Huinan Zhang, Yunhan Liu, Shaoyu Guan

Affiliation School of Nurse, the Fourth Military Medical University, Xi’an, China
⨯
Shaoyu Guan ,

Contributed equally to this work with: Huinan Zhang, Yunhan Liu, Shaoyu Guan

Affiliation Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi’an, China
⨯
Di Qu,

Affiliation Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi’an, China
⨯
Ling Wang,

Affiliation Department of Health Statistics, Faculty of Preventative Medicine, the Fourth Military Medical University, Xi’an, China
⨯
Xinshang Wang,

Affiliation Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi’an, China
⨯
Xubo Li,

Affiliation Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi’an, China
⨯
Shimeng Zhou,

Affiliation Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi’an, China
⨯
Ying Zhou,

Affiliation Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi’an, China
⨯
Ning Wang,

Affiliation Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi’an, China
⨯
Jingru Meng ,

* E-mail: maxuel@fmmu.edu.cn. (XM); mjrfmmu@hotmail.com (JM)

Affiliation Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi’an, China
⨯
Xue Ma

* E-mail: maxuel@fmmu.edu.cn. (XM); mjrfmmu@hotmail.com (JM)

Affiliation Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi’an, China
⨯

An Orally Active Allosteric GLP-1 Receptor Agonist Is Neuroprotective in Cellular and Rodent Models of Stroke

Huinan Zhang,
Yunhan Liu,
Shaoyu Guan,
Di Qu,
Ling Wang,
Xinshang Wang,
Xubo Li,
Shimeng Zhou,
Ying Zhou,
Ning Wang

Published: February 10, 2016
https://doi.org/10.1371/journal.pone.0148827

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Neurons
Is the Subject Area "Neurons" applicable to this article?

Thanks for your feedback.
Ischemic stroke
Is the Subject Area "Ischemic stroke" applicable to this article?

Thanks for your feedback.
Neuroprotectives
Is the Subject Area "Neuroprotectives" applicable to this article?

Thanks for your feedback.
Cerebral ischemia
Is the Subject Area "Cerebral ischemia" applicable to this article?

Thanks for your feedback.
Insulin
Is the Subject Area "Insulin" applicable to this article?

Thanks for your feedback.
Neuronal tuning
Is the Subject Area "Neuronal tuning" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Blood plasma
Is the Subject Area "Blood plasma" applicable to this article?

Thanks for your feedback.