Lentivirus-Mediated Knockdown of Astrocyte Elevated Gene-1 Inhibits Growth and Induces Apoptosis through MAPK Pathways in Human Retinoblastoma Cells

Ying Chang; Bin Li; Xiaolin Xu; Ling Shen; Haixia Bai; Fei Gao; Zhibao Zhang; Jost B. Jonas

doi:10.1371/journal.pone.0148763

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Peer-reviewed

Research Article

Lentivirus-Mediated Knockdown of Astrocyte Elevated Gene-1 Inhibits Growth and Induces Apoptosis through MAPK Pathways in Human Retinoblastoma Cells

Ying Chang,

Affiliation Beijing Institute of Ophthalmology, Beijing TongRen Eye Center, Beijing TongRen Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
⨯
Bin Li ,

* E-mail: libin43_99@163.com

Affiliation Beijing Institute of Ophthalmology, Beijing TongRen Eye Center, Beijing TongRen Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
⨯
Xiaolin Xu,

Affiliation Beijing Institute of Ophthalmology, Beijing TongRen Eye Center, Beijing TongRen Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
⨯
Ling Shen,

Affiliation Beijing Institute of Ophthalmology, Beijing TongRen Eye Center, Beijing TongRen Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
⨯
Haixia Bai,

Affiliation Beijing Institute of Ophthalmology, Beijing TongRen Eye Center, Beijing TongRen Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
⨯
Fei Gao,

Affiliation Beijing Institute of Ophthalmology, Beijing TongRen Eye Center, Beijing TongRen Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
⨯
Zhibao Zhang,

Affiliation Beijing Institute of Ophthalmology, Beijing TongRen Eye Center, Beijing TongRen Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
⨯
Jost B. Jonas

Affiliation Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany
⨯

Lentivirus-Mediated Knockdown of Astrocyte Elevated Gene-1 Inhibits Growth and Induces Apoptosis through MAPK Pathways in Human Retinoblastoma Cells

Ying Chang,
Bin Li,
Xiaolin Xu,
Ling Shen,
Haixia Bai,
Fei Gao,
Zhibao Zhang,
Jost B. Jonas

Published: February 19, 2016
https://doi.org/10.1371/journal.pone.0148763

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Apoptosis
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Lentivirus
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Transfection
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MAPK signaling cascades
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Malignant tumors
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Retinoblastoma
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Cancers and neoplasms
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ERK signaling cascade
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