Acute Systemic Infection with Dengue Virus Leads to Vascular Leakage and Death through Tumor Necrosis Factor-α and Tie2/Angiopoietin Signaling in Mice Lacking Type I and II Interferon Receptors

• Supranee Phanthanawiboon ,

  Contributed equally to this work with: Supranee Phanthanawiboon, Takeshi Kurosu

  Current address: Research and Diagnostic Center for Emerging Infectious Diseases, Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

  Affiliation Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

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• Kriengsak Limkittikul,

  Affiliation Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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• Yusuke Sakai,

  Current address: Laboratory of Veterinary Pathology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi-shi, Yamaguchi, Japan

  Affiliation Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

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• Nobuyuki Takakura,

  Affiliation Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

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• Masayuki Saijo,

  Affiliation Department of Virology I, National Institute of Infectious Diseases, Shinjyuku, Tokyo, Japan

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• Takeshi Kurosu

  Contributed equally to this work with: Supranee Phanthanawiboon, Takeshi Kurosu

  * E-mail: kurosu@niid.go.jp

  Current address: Department of Virology I, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan

  Affiliation Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

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