Protein Expression Profiling of Giant Cell Tumors of Bone Treated with Denosumab

Kenta Mukaihara; Yoshiyuki Suehara; Shinji Kohsaka; Keisuke Akaike; Yu Tanabe; Daisuke Kubota; Midori Ishii; Tsutomu Fujimura; Saiko Kazuno; Taketo Okubo; Tatsuya Takagi; Takashi Yao; Kazuo Kaneko; Tsuyoshi Saito

doi:10.1371/journal.pone.0148401

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Open Access

Peer-reviewed

Research Article

Protein Expression Profiling of Giant Cell Tumors of Bone Treated with Denosumab

Kenta Mukaihara,

Affiliation Department of Orthopedic Surgery, Juntendo University School of Medicine, Tokyo, Japan
⨯
Yoshiyuki Suehara ,

* E-mail: ysuehara@juntendo.ac.jp

Affiliation Department of Orthopedic Surgery, Juntendo University School of Medicine, Tokyo, Japan
⨯
Shinji Kohsaka,

Affiliation Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Keisuke Akaike,

Affiliation Department of Orthopedic Surgery, Juntendo University School of Medicine, Tokyo, Japan
⨯
Yu Tanabe,

Affiliation Department of Orthopedic Surgery, Juntendo University School of Medicine, Tokyo, Japan
⨯
Daisuke Kubota,

Affiliation Department of Orthopedic Surgery, Juntendo University School of Medicine, Tokyo, Japan
⨯
Midori Ishii,

Affiliation Department of Orthopedic Surgery, Juntendo University School of Medicine, Tokyo, Japan
⨯
Tsutomu Fujimura,

Affiliation Laboratory of Biochemical Analysis, Central Laboratory of Medical Sciences, Juntendo University School of Medicine, Tokyo, Japan
⨯
Saiko Kazuno,

Affiliation Laboratory of Biochemical Analysis, Central Laboratory of Medical Sciences, Juntendo University School of Medicine, Tokyo, Japan
⨯
Taketo Okubo,

Affiliation Department of Orthopedic Surgery, Juntendo University School of Medicine, Tokyo, Japan
⨯
Tatsuya Takagi,

Affiliation Department of Orthopedic Surgery, Juntendo University School of Medicine, Tokyo, Japan
⨯
Takashi Yao,

Affiliation Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan
⨯
Kazuo Kaneko,

Affiliation Department of Orthopedic Surgery, Juntendo University School of Medicine, Tokyo, Japan
⨯
Tsuyoshi Saito

Affiliation Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan
⨯

Protein Expression Profiling of Giant Cell Tumors of Bone Treated with Denosumab

Kenta Mukaihara,
Yoshiyuki Suehara,
Shinji Kohsaka,
Keisuke Akaike,
Yu Tanabe,
Daisuke Kubota,
Midori Ishii,
Tsutomu Fujimura,
Saiko Kazuno,
Taketo Okubo

Published: February 10, 2016
https://doi.org/10.1371/journal.pone.0148401

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Protein expression
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Computer software
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Giant cells
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Extracellular matrix proteins
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Cancer treatment
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Osteoclasts
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