Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair

Pengzhen Wang; Fengjie Zhang; Qiling He; Jianqi Wang; Hoi Ting Shiu; Yinglan Shu; Wing Pui Tsang; Shuang Liang; Kai Zhao; Chao Wan

doi:10.1371/journal.pone.0148372

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Open Access

Peer-reviewed

Research Article

Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair

Pengzhen Wang ,

Contributed equally to this work with: Pengzhen Wang, Fengjie Zhang

Affiliations Ministry of Education Key Laboratory of Regenerative Medicine (Jinan University - The Chinese University of Hong Kong), Guangzhou 510000, China, School of Biomedical Sciences Core Laboratory, Institute of Stem Cell, Genomics and Translational Research, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China
⨯
Fengjie Zhang ,

Contributed equally to this work with: Pengzhen Wang, Fengjie Zhang

Affiliations School of Biomedical Sciences Core Laboratory, Institute of Stem Cell, Genomics and Translational Research, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China, Ministry of Education Key Laboratory of Regenerative Medicine (The Chinese University of Hong Kong - Jinan University), School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
⨯
Qiling He,

Affiliation Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, United States of America
⨯
Jianqi Wang,

Affiliation Department of Chemistry, Faculty of Science, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
⨯
Hoi Ting Shiu,

Affiliation Ministry of Education Key Laboratory of Regenerative Medicine (The Chinese University of Hong Kong - Jinan University), School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
⨯
Yinglan Shu,

Affiliations School of Biomedical Sciences Core Laboratory, Institute of Stem Cell, Genomics and Translational Research, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China, Ministry of Education Key Laboratory of Regenerative Medicine (The Chinese University of Hong Kong - Jinan University), School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
⨯
Wing Pui Tsang,

Affiliations School of Biomedical Sciences Core Laboratory, Institute of Stem Cell, Genomics and Translational Research, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China, Ministry of Education Key Laboratory of Regenerative Medicine (The Chinese University of Hong Kong - Jinan University), School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
⨯
Shuang Liang,

Affiliations School of Biomedical Sciences Core Laboratory, Institute of Stem Cell, Genomics and Translational Research, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China, Ministry of Education Key Laboratory of Regenerative Medicine (The Chinese University of Hong Kong - Jinan University), School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
⨯
Kai Zhao,

Affiliations School of Biomedical Sciences Core Laboratory, Institute of Stem Cell, Genomics and Translational Research, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China, Ministry of Education Key Laboratory of Regenerative Medicine (The Chinese University of Hong Kong - Jinan University), School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
⨯
Chao Wan

* E-mail: cwan@cuhk.edu.hk

Affiliations Ministry of Education Key Laboratory of Regenerative Medicine (Jinan University - The Chinese University of Hong Kong), Guangzhou 510000, China, School of Biomedical Sciences Core Laboratory, Institute of Stem Cell, Genomics and Translational Research, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China, Ministry of Education Key Laboratory of Regenerative Medicine (The Chinese University of Hong Kong - Jinan University), School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
⨯

Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair

Pengzhen Wang,
Fengjie Zhang,
Qiling He,
Jianqi Wang,
Hoi Ting Shiu,
Yinglan Shu,
Wing Pui Tsang,
Shuang Liang,
Kai Zhao,
Chao Wan

Published: February 3, 2016
https://doi.org/10.1371/journal.pone.0148372

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Cell differentiation
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