Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes

• Jennifer E. Ho ,

  * E-mail: jho1@mgh.harvard.edu

  Affiliations Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University School of Medicine, Framingham, Massachusetts, United States of America, Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Martin G. Larson,

  Affiliations Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University School of Medicine, Framingham, Massachusetts, United States of America, Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, United States of America

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• Anahita Ghorbani,

  Affiliation Mount Auburn Hospital, Cambridge, Massachusetts, United States of America

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• Susan Cheng,

  Affiliations Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University School of Medicine, Framingham, Massachusetts, United States of America, Division of Cardiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Ming-Huei Chen,

  Affiliation Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University School of Medicine, Framingham, Massachusetts, United States of America

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• Michelle Keyes,

  Affiliation Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Eugene P. Rhee,

  Affiliations Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Renal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Clary B. Clish,

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Ramachandran S. Vasan,

  Affiliations Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University School of Medicine, Framingham, Massachusetts, United States of America, Division of Cardiology and Preventive Medicine, Department of Medicine, Boston University, Boston, Massachusetts, United States of America

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• Robert E. Gerszten ,

  Contributed equally to this work with: Robert E. Gerszten, Thomas J. Wang

  Affiliations Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Thomas J. Wang

  Contributed equally to this work with: Robert E. Gerszten, Thomas J. Wang

  Affiliation Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

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