Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells

Open Access

Peer-reviewed

Research Article

Generation and Characterisation of a Pax8-CreER^T2 Transgenic Line and a Slc22a6-CreER^T2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells

Judit Espana-Agusti,

Affiliation Department of Oncology, University of Cambridge, CRUK Cambridge institute, Cambridge, United Kingdom
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Xiangang Zou,

Affiliation Transgenics Facility, University of Cambridge, CRUK Cambridge institute, Cambridge, United Kingdom
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Kim Wong,

Affiliation Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
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Beiyuan Fu,

Affiliation Cytogenetics Facility, Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
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Fengtang Yang,

Affiliation Cytogenetics Facility, Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
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David A. Tuveson,

Current address: Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, United States of America

Affiliation Department of Oncology, University of Cambridge, CRUK Cambridge institute, Cambridge, United Kingdom
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David J. Adams,

Affiliation Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
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Athena Matakidou

* E-mail: Athena.Matakidou@cruk.cam.ac.uk

Affiliation Department of Oncology, University of Cambridge, CRUK Cambridge institute, Cambridge, United Kingdom
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Genetically modified animals
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Mouse models
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Renal cancer
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Kidneys
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Polymerase chain reaction
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Gene targeting
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Genetic loci
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Mammalian genomics
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