In Vivo Transplantation of Enteric Neural Crest Cells into Mouse Gut; Engraftment, Functional Integration and Long-Term Safety

Julie E. Cooper; Conor J. McCann; Dipa Natarajan; Shanas Choudhury; Werend Boesmans; Jean-Marie Delalande; Pieter Vanden Berghe; Alan J. Burns; Nikhil Thapar

doi:10.1371/journal.pone.0147989

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Open Access

Peer-reviewed

Research Article

In Vivo Transplantation of Enteric Neural Crest Cells into Mouse Gut; Engraftment, Functional Integration and Long-Term Safety

Julie E. Cooper,

Affiliation Stem Cells and Regenerative Medicine, UCL Institute of Child Health, 30 Guilford Street, London, United Kingdom
⨯
Conor J. McCann,

Affiliation Stem Cells and Regenerative Medicine, UCL Institute of Child Health, 30 Guilford Street, London, United Kingdom
⨯
Dipa Natarajan,

Affiliation Stem Cells and Regenerative Medicine, UCL Institute of Child Health, 30 Guilford Street, London, United Kingdom
⨯
Shanas Choudhury,

Affiliation Stem Cells and Regenerative Medicine, UCL Institute of Child Health, 30 Guilford Street, London, United Kingdom
⨯
Werend Boesmans,

Affiliation Laboratory for Enteric NeuroScience, Translational Research Center for GastroIntestinal Disorders, Department of Clinical and Experimental Medicine, University of Leuven, Leuven, Belgium
⨯
Jean-Marie Delalande,

Affiliations Stem Cells and Regenerative Medicine, UCL Institute of Child Health, 30 Guilford Street, London, United Kingdom, Centre for Digestive Diseases, Blizard Building, Barts & The London School of Medicine & Dentistry, Queen Mary, University of London, London, United Kingdom
⨯
Pieter Vanden Berghe,

Affiliation Laboratory for Enteric NeuroScience, Translational Research Center for GastroIntestinal Disorders, Department of Clinical and Experimental Medicine, University of Leuven, Leuven, Belgium
⨯
Alan J. Burns ,

* E-mail: n.thapar@ucl.ac.uk (NT); alan.burns@ucl.ac.uk (AJB)

Affiliations Stem Cells and Regenerative Medicine, UCL Institute of Child Health, 30 Guilford Street, London, United Kingdom, Department of Clinical Genetics, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
⨯
Nikhil Thapar

* E-mail: n.thapar@ucl.ac.uk (NT); alan.burns@ucl.ac.uk (AJB)

Affiliations Stem Cells and Regenerative Medicine, UCL Institute of Child Health, 30 Guilford Street, London, United Kingdom, Department of Gastroenterology, Great Ormond Street Hospital NHS Foundation Trust, Great Ormond Street, London, United Kingdom
⨯

In Vivo Transplantation of Enteric Neural Crest Cells into Mouse Gut; Engraftment, Functional Integration and Long-Term Safety

Julie E. Cooper,
Conor J. McCann,
Dipa Natarajan,
Shanas Choudhury,
Werend Boesmans,
Jean-Marie Delalande,
Pieter Vanden Berghe,
Alan J. Burns,
Nikhil Thapar

Published: January 29, 2016
https://doi.org/10.1371/journal.pone.0147989

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